Neural Plasticity / 2016 / Article / Tab 1

Review Article

Linking Mitochondria to Synapses: New Insights for Stress-Related Neuropsychiatric Disorders

Table 1

Summary of the cellular and physiological effects of BDNF, glucocorticoids, stress, major depressive disorders, and antidepressant therapies.

BDNFGlucocorticoidsStressMajor depressionAntidepressant therapies

Synaptic structureFormation, maintenanceFormation, elimination, and maintenanceFormation, eliminationEliminationFormation, maintenance
Synaptic functionPotentiationPotentiation, depressionPotentiation, depressionDepressionPotentiation
Mitochondria structure BiogenesisAugmented/diminishedAugmented/diminished#DiminishedAugmented/diminished
Mitochondria energetics functionAugmented Augmented/diminishedAugmented/diminishedDiminishedAugmented/diminished
Mitochondria redox functionAugmentedAugmented/diminishedAugmented/diminished#DiminishedAugmented
Learning and memoryAugmentedAugmented/diminished#Augmented/diminished#Diminished Augmented#
Despair and anxietyDiminishedAugmented/diminished#Augmented/diminished#Augmented Diminished#

#: effect depends on the dose, duration, and context at exposure.
: effect is specific of the brain region.
: effect demonstrated in cultured cells.

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