Early Transcriptional Changes Induced by Wnt/β-Catenin Signaling in Hippocampal Neurons

Figure 2

Functional relationships of Wnt differentially expressed genes. Nominal Wnt-induced differentially expressed genes are presented () alongside their mayor functional interactions. Node color represents the observed fold change (FC) upon Wnt3a treatment in a gradient from green (downregulation) to red (upregulation) values (i.e., green: FC < 1; red FC > 1; white: FC = 1). Similarly, node size is proportional to the    value assigned by DESeq to the gene. Central boxes denote the top 5 overrepresented GO categories and their respective gene associations (color edges) which are presented for neural precursor (GO:0061364), forebrain development (GO:0030900), stem cell differentiation (GO:0048863), brain development (GO:0007420), and gland development (GO:0048732) categories. Direct functional interactions extracted from STRING are shown with black edges. Hexagon-shaped nodes show top 25 genes differentially expressed. Diamond-shaped node highlight top 1 differentially expressed gene (Fam68a). Black and grey node borders denote top 20 Wnt target or functional evidence, respectively.