Blockade of Toll-Like Receptors (TLR2, TLR4) Attenuates Pain and Potentiates Buprenorphine Analgesia in a Rat Neuropathic Pain Model

Figure 3

Western blot analysis of IBA-1 (a, b), TLR2 (c, d), TLR4 (e, f), MyD88 (g, h), and TRIF (i, j) protein levels in the ipsilateral dorsal lumbar spinal cord (a, c, e, g, and i) and DRG (b, d, f, h, and j) tissue on 2nd, 7th, and 14th days after chronic constriction injury (CCI) in rats. The data are presented as the mean ± SEM of 4–7 samples per group. Intergroup differences were analyzed using one-way ANOVA followed by Bonferroni’s multiple comparisons test. , , and indicate significant differences versus the INTACT group.