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Neural Plasticity
Volume 2016, Article ID 5238730, 12 pages
Research Article

Blockade of Toll-Like Receptors (TLR2, TLR4) Attenuates Pain and Potentiates Buprenorphine Analgesia in a Rat Neuropathic Pain Model

Department of Pain Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, 31-343 Krakow, Poland

Received 7 May 2015; Revised 7 September 2015; Accepted 20 September 2015

Academic Editor: Shao-Jun Tang

Copyright © 2016 Agnieszka M. Jurga et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Protein and mRNA levels of TLR2, TLR4 and their adaptor molecules: MyD88 and TRIF are upregulated in spinal cord and/or DRG as measured in three time points during 14-day course of neuropathy development. Pharmacological blockade of Toll-like receptors (TLR2, TLR4) with endogenous antagonists - LPS-RS and LPS-RS Ultrapure, has evoked analgesia in rat CCI neuropathic pain model and potentiated buprenorphine antinociceptive effect.

  1. Supplementary Material