Inhibition of the cAMP/PKA/CREB Pathway Contributes to the Analgesic Effects of Electroacupuncture in the Anterior Cingulate Cortex in a Rat Pain Memory Model

Figure 3

EA alleviated the retrieval of pain memory. The rats in the pain memory model were divided into the control, model, indo, EA, and sham EA groups, and the mechanical allodynia in each group was examined (). (a) On the left hind paw (first injected), EA or indomethacin treatment increased the PWTs significantly compared with the model group. (b) There was no significant difference in all groups at the same period. (c) On the left hind paw (second noninjected), the PWTs in the model group decreased significantly compared with the control group and its baseline. EA treatment administered at the first injection time point inhibited this progress. (d) The second injection of carrageenan into the right hind paw significantly decreased the PWTs of the carrageenan-injected groups compared with the control group and their baselines. Error bars indicate the SEM. and , versus the control group; and , versus the model group; , versus the indo group; and , versus the sham EA group; , versus baseline.

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