TY - JOUR A2 - Cocks, Graham AU - Feldman, Danielle AU - Banerjee, Abhishek AU - Sur, Mriganka PY - 2016 DA - 2016/01/31 TI - Developmental Dynamics of Rett Syndrome SP - 6154080 VL - 2016 AB - Rett Syndrome was long considered to be simply a disorder of postnatal development, with phenotypes that manifest only late in development and into adulthood. A variety of recent evidence demonstrates that the phenotypes of Rett Syndrome are present at the earliest stages of brain development, including developmental stages that define neurogenesis, migration, and patterning in addition to stages of synaptic and circuit development and plasticity. These phenotypes arise from the pleotropic effects of MeCP2, which is expressed very early in neuronal progenitors and continues to be expressed into adulthood. The effects of MeCP2 are mediated by diverse signaling, transcriptional, and epigenetic mechanisms. Attempts to reverse the effects of Rett Syndrome need to take into account the developmental dynamics and temporal impact of MeCP2 loss. SN - 2090-5904 UR - https://doi.org/10.1155/2016/6154080 DO - 10.1155/2016/6154080 JF - Neural Plasticity PB - Hindawi Publishing Corporation KW - ER -