Social Isolation Stress Induces Anxious-Depressive-Like Behavior and Alterations of Neuroplasticity-Related Genes in Adult Male Mice
(a) Experimental schedule. Nine-week-old male mice were housed in groups (GH) or socially isolated (SI) throughout the experimental period. The open field test (OFT) and the tail suspension test (TST) were conducted on days 28 and 31, respectively. Animals were sacrificed on day 33. (b–e) Chronic adult social isolation stress induced hyperactivity and anxiety- and depressive-like behaviors in male mice. In the OFT, SI mice showed reduced percentage of time spent in the center (b), increased total distance travelled (d), and only a tendency to decreased percentage of distance travelled in the center (c). In the TST, SI mice showed increased total immobility time (e). Data are presented as mean ± SEM (-8 per group). ; .
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