Social Isolation Stress Induces Anxious-Depressive-Like Behavior and Alterations of Neuroplasticity-Related Genes in Adult Male Mice
Social isolation stress in adulthood decreases expression of neuroplasticity-related gene in the hippocampus (HPC) and prefrontal cortex (PFC). (a, b) In socially isolated (SI) adult male mice, mGluR1 and mGluR2 mRNA levels were reduced in the PFC (b). No differences were revealed for mGluR5 in the PFC and for mGluR1, mGluR2, and mGluR5 in the HPC (a-b). SI mice showed reduced mRNA levels of c-Fos, Arc, and Egr-1 in the HPC and PFC (c-d). Data are presented as mean ± SEM (-8 per group). .
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