Brain Responses during the Anticipation of Dyspnea

Figure 5

(a) Backward model: right insular activation during dyspnea perception is significantly correlated with midbrain/PAG activation during dyspnea anticipation (, , ; ROI-corrected ). (b) Anticipatory fear is significantly correlated with increased brain activation during dyspnea anticipation in the ACC (, , ; ROI-corrected ) and right insular cortex (, , ; ROI-corrected ). The nonsignificant correlations with the putamen and medial prefrontal cortex (b) were outside our ROIs and did not reach whole-brain-corrected significance. All correlations are displayed at a threshold of , corrected for the specific ROI, and superimposed on the group-specific T1-weighted mean image generated by the DARTEL-protocol.

(a)

(b)