Phosphorylation of CRMP2 by Cdk5 Regulates Dendritic Spine Development of Cortical Neuron in the Mouse Hippocampus

Figure 4

Reduction of dendritic spine density in hippocampal CA1 pyramidal neurons in 5 week-old mice. (a) Representative photographs of dendritic segments of hippocampal CA1 pyramidal neurons at 5 weeks old. Scale bar, 10 μm. (b) Reduced dendritic spine density was observed in hippocampal CA1 pyramidal neurons of mice compared to those of control mice. 50 neurons in each area from three mice in each genotype were analyzed. .

(a)

(b)