A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice

Figure 2

Body weight was measured in 10–12-month-old (a) and 16–18-month-old ApoE4 and wild-type (WT) mice. (a) At 10 months of age, ApoE4 and also wild-type mice on Fortasyn were significantly heavier than on control diet (ApoE4: ; wild-type: ). Only on Fortasyn diet was a genotype effect found showing a higher weight of ApoE4 mice compared with wild-type mice (). Again at 12 months of age, all animals on Fortasyn diet showed an increased body weight compared to animals on control diet (ApoE4: ; wild-type: ). ApoE4 mice on Fortasyn were heavier than wild-type mice on the same diet (). (b) At 16 and also 18 months of age, ApoE4 mice were significantly lighter than wild-type mice (16-month: ; 18-month: ). Furthermore, all animals on Fortasyn were heavier than animals on control diet (16-month: ; 18-month: ). ; ; .

(a)

(b)