Transcriptional Control of Synaptic Plasticity by Transcription Factor NF-κB

Figure 1

Overview of NF-κB regulated components in synaptic plasticity. (1) At the postsynapse NF-κB regulates the expression of various components of the postsynaptic density, ion channels/receptors, signaling molecules, and transcription factors that are involved in the modulation of synaptic transmission. (2) In inhibitory neurons, NF-κB regulates the expression of GAD65 that is required for GABA synthesis. (3) Synaptic plasticity is further modulated by paracrine release of neurotrophic factors from adjacent cells. In astrocytes, activation of NF-κB led to the secretion of BNDF, and (4) microglia express the NF-κB target gene IL-1β. For references, see Table 1.