Review Article

Spindle Oscillations in Sleep Disorders: A Systematic Review

Table 3

Sleep-Related Movement Disorders/Parasomnia.

StudySampleDemographicsMeds at StudyMeasurementTarget variablesResults

Restless Legs Syndrome
(i) Spectral analysis
Hornyak et al., 2005 [105]Clinical: idiopathic restless legs syndrome (RLS),
Control:
Clinical:  yr, 50% ♂
Control:  yr, 50% ♂
NoOne all-night PSG; SR = 200 Hz; FFT w/30-sec eph on C3Absolute sigma power (12–16 Hz) during total NREM and REM sleep, and in NREM2 and REM epochs with (a) arousals, (b) leg movements, and (c) leg movements + arousalsNo group differences
Ferri et al., 2014 [106]Clinical 1: idiopathic RLS,
Clinical 2: chronic primary insomnia,
Control:
Clinical 1:  yr, 56% ♂
Clinical 2:  yr, 45% ♂
Control:  yr, 50% ♂
NoTwo all-night PSGs (1 adaptation); SR = 128 Hz; FFT w/4-sec eph on C3 or C4 from night 2Absolute and relative sigma power (11.75–14.75 Hz) in the 5 min before and after sleep-onset period (SOP)No group differences

NREM parasomnia
(i) Event Analysis-automatic
Espa et al., 2000 [107]Clinical:  w/sleepwalking (SW) and/or sleep terrors,
Control:
Clinical: (22–40) yr, 45% ♂
Control:  yr, 45% ♂
NoTwo all-night PSGs (1 adaptation); SR = 128 Hz; Integrated digital filtering analysis on C3 and C4 from night 2Sleep spindle index (SSI; 13–17 Hz) across consecutive NREM-REM sleep cycles, and during each of NREM2, NREM3, and REM sleep both overall and in consecutive sleep cycles(1) SSI lower in PA versus controls during the 2nd and 4th NREM-REM sleep cycle; (2) SSI lower in PA vs. controls during total NREM3, and during the 2nd and 4th NREM3 cycle
(ii) Spectral analysis
Espa et al., 2000 [107]Clinical:  w/sleepwalking (SW) and/or sleep terrors,
Control:
Clinical: (22–40) yr, 45% ♂
Control:  yr, 45% ♂
NoTwo all-night PSGs (1 adaptation); SR = 128 Hz; FFT w/avg of 5 4-sec eph on C3 and C4 from night 2Absolute sigma power (13–17 Hz) during total NREM and REM sleep; relative power in the 2nd, 3rd, and 4th NREM and REM cycles, expressed as a percentage of power in the 1st cycleNo group differences
Guilleminault et al., 2006 [108]Clinical:  SW,
Control:
Clinical:  yr, 70% ♂
Control:  yr, 70% ♂
?One all-night PSG; SR = 256 Hz; FFT w/avg of 15 4-sec eph on C4Relative sigma power (12.25–16 Hz) during total NREM No group differences

REM parasomnias
(i) Event Analysis-automatic
Christensen et al., 2014 [109]Clinical 1: idiopathic REM behaviour disorder (iRBD),
Clinical 2: Parkinson’s + RBD (PD + RBD),
Clinical 3: Parkinson’s without RBD (PD − RBD)
Control:
Clinical 1:  yr, 80% ♂
Clinical 2:  yr, 73% ♂
Clinical 3:  yr, 53% ♂
Control:  yr, 40% ♂
Only dopamine-acting meds allowedOne all-night PSG; SR = ? Hz; Auto spindle scoring on F3, C3Sleep spindle (11–16 Hz) density during total NREM, NREM1–4 separately, and REM(1) PD + RBD and iRBD had lower spindle density versus controls in NREM2, NREM3, and total NREM (), while PD-RBD had lower spindle density versus controls only during NREM2 and total NREM () (PD + RBD < iRBD < PD − RBD < controls); (2) no group differences during REM
O’Reilly et al., 2015 [110]Clinical: RBD,
Control:
Clinical:  yr, 80% ♂
Control:  yr, 80% ♂
?? all-night PSG; SR = 256 Hz; auto spindle scoring on 19 EEG sites using data pooled from various studies/assessmentsSleep spindle (11–16 Hz) mean density and topographical distribution during NREM2 (1) RBD had 6–35% lower overall spindle density maximal on central and parietal derivations; (2) RBD had lower fast spindle density in some frontal, and all examined central, parietal, temporal, and occipital derivations; (3) RBD had higher slow spindle density in F3/4, C3/4, P3/4, O1/2, and T3/5/6
(ii) Spectral analysis
Massicotte-Marquez et al., 2005 [111]Clinical: idiopathic RBD,
Control: ,
Clinical: (52–77) yr, 75% ♂
Control: (51–81) yr, 75% ♂
NoOne all-night PSG; SR = 256 Hz; FFT w/avg of 5 4-sec eph on C3Absolute sigma1 (12–14 Hz) and sigma 2 (14–16 Hz) power for total NREM and for the first three NREM cycles No group differences
Simor et al., 2013 [112]Clinical: with nightmares (NM)
Control:
Clinical:  yr, 53% ♂
Control:  yr, 52% ♂
NoTwo all-night PSGs (1 adaptation); SR = 1024 Hz; FFT w/4-sec eph across 19 EEG derivations from night 2Relative spectral power in 0.25 Hz bins during whole-night NREM, and “high alpha” (10–14.5 Hz) during REM(1) No group differences in sigma power during NREM; (2) NM had higher 10–14.5 Hz “high alpha” activity during REM across scalp regions, especially over the left temporo-occipital area

?: unmentioned; ♂: male; Meds at Study: participants taking medication at time of sleep study; eph: epoch; sec: second; min: minute; SR: sampling rate; Hz: Hertz; RLS: restless legs syndrome; SW: sleepwalkers; NM: nightmare sufferers; PA: combined parasomnia group; RBD: REM behaviour disorder; PD + RBD: Parkinson’s disease with RBD.
Study is listed twice for providing both event analysis and spectral analysis data.