Research Article

A High-Fat Diet Causes Impairment in Hippocampal Memory and Sex-Dependent Alterations in Peripheral Metabolism

Figure 6

Memory assessed via spatial object recognition (SOR). The task was performed in a 60 × 60 × 60 cm walled open field, with 15 × 15 cm gridlines on the floor and spatial cues positioned on adjacent walls (a). Identical objects were 5 cm solid aluminum cubes. For training, rats were allowed to explore the open field with two objects in defined locations. For testing, rats were again allowed to explore the open field, now with one object in the original location, and one object moved to a novel location (b). The subjects were fully acclimated to handling and to the open field prior to training and testing (c).