Potential Role of JAK-STAT Signaling Pathway in the Neurogenic-to-Gliogenic Shift in Down Syndrome Brain

Table 1

Cytokines and their corresponding specific receptors in JAK-STAT signaling activation.

	Ligands	Receptor	JAK kinases	STATs
IFN family	IFN-α/β	IFNAR	JAK1, TYK2	STAT1, STAT2, STAT3, STAT5a/5b
	IFN-γ	IFNGR	JAK1, JAK2	STAT1, STAT3, STAT5a/5b
	IL-10	IL-10R	JAK1, TYK2	STAT1, STAT3
gp 130 family	IL-6	gp130	JAK1, JAK2	STAT1, STAT3
	IL-11	gp130	JAK1	STAT1, STAT3
	IL-12	IL-12R	JAK2, TYK2	STAT4
	CNTF	gp130 and LIFRβ	JAK1, JAK2	STAT1, STAT3
	LIF	gp130 and LIFRβ	JAK1, JAK2	STAT1, STAT3
	OSM	gp130 and OSMR	JAK1, JAK2	STAT1, STAT3
	CT-1	gp130 and LIFRβ	JAK1, JAK2	STAT3
	G-CSF	G-CSFR	JAK1, JAK2	STAT3
	Leptin	LEPR	JAK2	STAT3
βc family	IL-3	IL-3R	JAK2	STAT5a/5b
	IL-5	IL-5R	JAK2	STAT5a/5b
	GM-CSF	GM-CSFR	JAK2	STAT5a/5b
γ-chain (gC) family	IL-2; IL-7; IL-9; IL15	IL-2R; IL-7R; IL-9R; IL-15R	JAK1, JAK3	STAT1, STAT3,; STAT4, STAT5a/5b
	IL-4	IL-4R	JAK1, JAK3	STAT6
	IL-13	IL-13R	JAK1, JAK2, TYK2	STAT6