Enhanced Neuroplasticity by the Metabolic Enhancer Piracetam Associated with Improved Mitochondrial Dynamics and Altered Permeability Transition Pore Function

Figure 1

Piracetam improves neurite outgrowth under normal conditions in SH-SY5Y APPwt cells only. SH-SY5Y Ctl cells were seeded and incubated for one day. Afterwards, incubation was started with 1 mM piracetam (Pira). After 72 hours, cells were fixed and stained for analysis of neurite outgrowth. In SH-SY5Y Ctl cells, no statically significant effect was observed. In contrast, SH-SY5Y APPwt cells benefit from the incubation with piracetam and possess longer neurites. Data are represented as mean ± SEM; Student’s unpaired -test (, compared to untreated control cells); = 8–14.