Neural Plasticity / 2016 / Article / Fig 7

Research Article

Long-Standing Motor and Sensory Recovery following Acute Fibrin Sealant Based Neonatal Sciatic Nerve Repair

Figure 7

Frequency distribution of axon diameter of regenerated fibers, 4, 8, and 12 weeks, following P2 sciatic nerve transection and repair. (a, b) Ipsilateral side, 4 weeks after lesion, groups AX+FS and AX+CFS, respectively. (c) Contralateral side, 4 weeks after lesion. (d, e) Ipsilateral side, 8 weeks after lesion, groups AX+FS and AX+CFS, respectively. (f) Contralateral side, 8 weeks after lesion. (g, h) Ipsilateral side, 12 weeks after lesion, groups AX+FS and AX+CFS, respectively. (i) Contralateral side, 12 weeks after lesion. Note smaller axon diameters in the group AX+CFS, 4 weeks after lesion. Red boxes highlight frequency intervals with greater differences among groups. (AX) axotomy; (AX+FS) axotomy followed by coaptation with fibrin sealant derived from snake venom; (AX+CFS) axotomy followed by coaptation with commercial fibrin sealant.