Long-Standing Motor and Sensory Recovery following Acute Fibrin Sealant Based Neonatal Sciatic Nerve Repair

Figure 9

Frequency distribution of ratio of regenerated fibers and dot plot of g ratio/axon diameter, 4, 8, and 12 weeks, following P2 sciatic nerve transection and repair. (a, b) Ipsilateral side, 4 weeks after lesion, groups AX+FS and AX+CFS, respectively. (c) Contralateral side, 4 weeks after lesion. (d, e) Ipsilateral side, 8 weeks after lesion, groups AX+FS and AX+CFS, respectively. (f) Contralateral side, 8 weeks after lesion. (g, h) Ipsilateral side, 12 weeks after lesion, groups AX+FS and AX+CFS, respectively. (i) Contralateral side, 12 weeks after lesion. Observe the shift toward the presence of greater axons with close to normal myelin thickness in both coaptation groups in all survival times analyzed. (AX) axotomy; AX+FS: axotomy followed by coaptation with fibrin sealant derived from snake venom; AX+CFS: axotomy followed by coaptation with commercial fibrin sealant.