Correlations between the Memory-Related Behavior and the Level of Oxidative Stress Biomarkers in the Mice Brain, Provoked by an Acute Administration of CB Receptor Ligands

Table 1

Effects of CB2 receptor agonist, JWH 133 (a), CB2 receptor antagonist, AM 630 (b), CB1/CB2 receptor agonist, WIN 55,212-2 (c), and CB1 receptor antagonist, AM 251 (d), on the locomotor activity. The data are shown as the means ± SEM; photocell beam breaks of mice were measured immediately after injection for 60 min; –10.

(a)

Drugs	Photocell beam breaks ± SEM (60 min)
Vehicle	588.9 ± 61.20
JWH 133 (0.25 mg/kg)	611.7 ± 25.11
JWH 133 (0.5 mg/kg)	644.2 ± 74.15
JWH 133 (1.0 mg/kg)	606.5 ± 45.15
JWH 133 (2.0 mg/kg)	621.3 ± 47.77

(b)

Drugs	Photocell beam breaks ± SEM (60 min)
Vehicle	597.0 ± 29.63
AM 630 (0.25 mg/kg)	646.25 ± 26.45
AM 630 (0.5 mg/kg)	677.84 ± 34.69
AM 630 (1.0 mg/kg)	743.01 ± 42.86
AM 630 (2.0 mg/kg)	724.44 ± 22.05
AM 630 (3.0 mg/kg)	712.9 ± 73.16

(c)

Drugs	Photocell beam breaks ± SEM (60 min)
Vehicle	588.9 ± 61.20
WIN 55,212-2 (0.25 mg/kg)	490.5 ± 77.03
WIN 55,212-2 (0.5 mg/kg)	422.6 ± 87.20
WIN 55,212-2 (1.0 mg/kg)	414.8 ± 74.71

(d)

Drugs	Photocell beam breaks ± SEM (60 min)
Vehicle	555.15 ± 48.12
AM 251 (0.25 mg/kg)	406.0 ± 60.29
AM 251 (0.5 mg/kg)	394.71 ± 24.43
AM 251 (1.0 mg/kg)	445.54 ± 42.07
AM 251 (3.0 mg/kg)	517.5 ± 40.66