Research Article

CB2 Cannabinoid Receptor Knockout in Mice Impairs Contextual Long-Term Memory and Enhances Spatial Working Memory

Figure 3

The levels of motor activity and anxiety assessed in an open field arena are normal in CB2R KO mice. (a) Representative tracking of mouse movement for 5 min in an open field arena (40 × 40 cm2). (b–e) During the 5 min exploration period, KO and WT mice showed no significant difference from each other in the time spent in the center area (20 × 20 cm2) of the arena (b), the travel distance in the center area (c), the total travel distance in the arena (d), or the mean speed of movement (e). Error bars represent SEM.