CB2 Cannabinoid Receptor Knockout in Mice Impairs Contextual Long-Term Memory and Enhances Spatial Working Memory
The levels of motor activity and anxiety assessed in an open field arena are normal in CB2R KO mice. (a) Representative tracking of mouse movement for 5 min in an open field arena (40 × 40 cm2). (b–e) During the 5 min exploration period, KO and WT mice showed no significant difference from each other in the time spent in the center area (20 × 20 cm2) of the arena (b), the travel distance in the center area (c), the total travel distance in the arena (d), or the mean speed of movement (e). Error bars represent SEM.