Research Article

CB2 Cannabinoid Receptor Knockout in Mice Impairs Contextual Long-Term Memory and Enhances Spatial Working Memory

Figure 4

The anxiety level of CB2R KO mice is similar to that of WT mice when assayed in an elevated zero maze. (a) Representative tracking of mice in an elevated zero maze for 5 min. Dashed lines indicate the walls in two closed quadrants. (b-c) KO and WT mice spent similar time (b) and traveled similar distances (c) in the closed quadrants of the zero maze. (d) The total travel distance of KO mice in the zero maze for 5 min was not significantly different from that of WT mice. Error bars represent SEM.