Wnt5a Increases the Glycolytic Rate and the Activity of the Pentose Phosphate Pathway in Cortical Neurons

Figure 1

Wnt5a stimulates glucose uptake. (a) Treatment with Wnt5a stimulates the uptake of 2-DG in a time-dependent manner. (b) The effect of Wnt5a was blocked by the antagonist FzCRD2 and with 7NI a nNOs inhibitor. (c–e) The initial uptake of tracer amounts of 2-DG (at 15 sec.) was measured in the presence of increasing concentrations of unlabeled glucose (0–30 mM), under the control condition (c) and in cells treated with Wnt5a (d). Representative plot of both conditions (e). Data represent the mean ± SEM of , each performed in triplicate. , Bonferroni test.

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