Wnt5a Increases the Glycolytic Rate and the Activity of the Pentose Phosphate Pathway in Cortical Neurons

Figure 3

The Wnt5a stimulates the PPP activity. (a) The activation of Wnt pathways increases the activity of G6PDH in a time-dependent manner (i); this effect was blocked by the coincubation with FzdCRD-2 and 7NI (ii). (b) The oxidation of glucose through PPP pathway was stimulated after the treatment with Wnt5a; this effect was blocked by the coincubation with FzdCRD-2. Data represent the mean ± SEM of , each performed in triplicate. ; , Bonferroni test.

(a)

(b)