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Neural Plasticity
Volume 2017, Article ID 1389475, 15 pages
https://doi.org/10.1155/2017/1389475
Review Article

Assessed and Emerging Biomarkers in Stroke and Training-Mediated Stroke Recovery: State of the Art

1Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy
2UOC Neurorehabilitation, AOUI Verona, Verona, Italy
3Immunology Unit, Azienda Ospedaliera Universitaria Integrata, Verona, Italy

Correspondence should be addressed to Marialuisa Gandolfi; ti.rvinu@iflodnag.asiulairam

Received 9 November 2016; Accepted 11 January 2017; Published 8 March 2017

Academic Editor: Annalena Venneri

Copyright © 2017 Marialuisa Gandolfi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Q. Ji, Y. Ji, J. Peng et al., “Increased brain-specific MiR-9 and MiR-124 in the serum exosomes of acute ischemic stroke patients,” PLoS ONE, vol. 11, no. 9, Article ID e0163645, 2016. View at Publisher · View at Google Scholar
  2. M. Kacperska, J. Walenczak, and B. Tomasik, “Plasmatic microRNA as potential biomarkers of multiple sclerosis: literature review,” Advances in Clinical and Experimental Medicine, vol. 25, no. 4, pp. 775–779, 2016. View at Publisher · View at Google Scholar
  3. P. H. Reddy, S. Tonk, S. Kumar et al., “A critical evaluation of neuroprotective and neurodegenerative MicroRNAs in Alzheimer's disease,” Biochemical and Biophysical Research Communications, 2016. View at Publisher · View at Google Scholar
  4. L. Qiu, E. K. I. Tan, and L. Zeng, “microRNAs and neurodegenerative diseases,” Advances in Experimental Medicine and Biology, vol. 888, pp. 85–105, 2015. View at Publisher · View at Google Scholar · View at Scopus
  5. Y. Xie and Y. Chen, “microRNAs: emerging targets regulating oxidative stress in the models of Parkinson's disease,” Frontiers in Neuroscience, vol. 10, article no. 298, 2016. View at Publisher · View at Google Scholar · View at Scopus
  6. N. Quillinan, P. S. Herson, and R. J. Traystman, “Neuropathophysiology of brain injury,” Anesthesiology Clinics, vol. 34, no. 3, pp. 453–464, 2016. View at Publisher · View at Google Scholar
  7. M. S. V. Elkind, “Inflammatory markers and stroke,” Current Cardiology Reports, vol. 11, no. 1, pp. 12–20, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. R. B. Schnabel and S. Blankenberg, “Commentary: Circulating cytokines and risk stratification of stroke incidence—will we do better in future?” International Journal of Epidemiology, vol. 38, no. 1, pp. 261–262, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. H. J. Coelho Junior, B. B. Gambassi, T. A. Diniz et al., “Inflammatory mechanisms associated with skeletal muscle sequelae after stroke: role of physical exercise,” Mediators of Inflammation, vol. 2016, Article ID 3957958, 19 pages, 2016. View at Publisher · View at Google Scholar
  10. A. P. Lightfoot and R. G. Cooper, “The role of myokines in muscle health and disease,” Current Opinion in Rheumatology, vol. 28, no. 6, pp. 661–666, 2016. View at Publisher · View at Google Scholar
  11. A. Tuttolomondo, A. Casuccio, V. Della Corte et al., “Endothelial function and arterial stiffness indexes in subjects with acute ischemic stroke: relationship with TOAST subtype,” Atherosclerosis, vol. 256, pp. 94–99, 2017. View at Publisher · View at Google Scholar
  12. S. Koton, D. Tanne, and E. Grossman, “Prestroke treatment with beta-blockers for hypertension is not associated with severity and poor outcome in patients with ischemic stroke,” Journal of Hypertension, 2016. View at Publisher · View at Google Scholar
  13. Z. Wang, G. Hao, X. Wang et al., “Short-term hypertension management in community is associated with long-term risk of stroke and total death in China: a community controlled trial,” Medicine, vol. 95, no. 48, p. e5245, 2016. View at Publisher · View at Google Scholar
  14. J. C. Kupferman, D. I. Zafeiriou, M. B. Lande, F. J. Kirkham, and S. G. Pavlakis, “Stroke and hypertension in children and adolescents,” Journal of Child Neurology, vol. 32, no. 4, pp. 408–417, 2017. View at Publisher · View at Google Scholar
  15. R. Chen, B. Ovbiagele, and W. Feng, “Diabetes and stroke: epidemiology, pathophysiology, pharmaceuticals and outcomes,” The American Journal of the Medical Sciences, vol. 351, no. 4, pp. 380–386, 2016. View at Publisher · View at Google Scholar
  16. S. Sacco, F. Stracci, D. Cerone, S. Ricci, and A. Carolei, “Epidemiology of stroke in Italy,” International Journal of Stroke, vol. 6, no. 3, pp. 219–227, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. V. Arnao, M. Acciarresi, E. Cittadini, and V. Caso, “Stroke incidence, prevalence and mortality in women worldwide,” International Journal of Stroke, vol. 11, no. 3, pp. 287–301, 2016. View at Publisher · View at Google Scholar · View at Scopus
  18. T. Truelsen, B. Piechowski-Jóźwiak, R. Bonita, C. Mathers, J. Bogousslavsky, and G. Boysen, “Stroke incidence and prevalence in Europe: a review of available data,” European Journal of Neurology, vol. 13, no. 6, pp. 581–598, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. A. Shoamanesh, S. R. Preis, A. S. Beiser et al., “Circulating biomarkers and incident ischemic stroke in the Framingham Offspring Study,” Neurology, vol. 87, no. 12, pp. 1206–1211, 2016. View at Publisher · View at Google Scholar
  20. O. S. Mattila, H. Harve, S. Pihlasviita et al., “Ultra-acute diagnostics for stroke: large-scale implementation of prehospital biomarker sampling,” Acta Neurologica Scandinavica, 2016. View at Publisher · View at Google Scholar
  21. B. K. Pedersen, “Exercise-induced myokines and their role in chronic diseases,” Brain, Behavior, and Immunity, vol. 25, no. 5, pp. 811–816, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. J. Dong, Y. Dong, Y. Dong, F. Chen, W. E. Mitch, and L. Zhang, “Inhibition of myostatin in mice improves insulin sensitivity via irisin-mediated cross talk between muscle and adipose tissues,” International Journal of Obesity, vol. 40, no. 3, pp. 434–442, 2016. View at Publisher · View at Google Scholar · View at Scopus
  23. J. Zhang and W. Zhang, “Can irisin be a linker between physical activity and brain function?” Biomolecular Concepts, vol. 7, no. 4, pp. 253–258, 2016. View at Publisher · View at Google Scholar
  24. A. Kalinkovich and G. Livshits, “Sarcopenia—the search for emerging biomarkers,” Ageing Research Reviews, vol. 22, pp. 58–71, 2015. View at Publisher · View at Google Scholar · View at Scopus
  25. R. G. Walker, T. Poggioli, L. Katsimpardi et al., “Biochemistry and biology of GDF11 and myostatin: similarities, differences, and questions for future investigation,” Circulation Research, vol. 118, no. 7, pp. 1125–1142, 2016. View at Publisher · View at Google Scholar
  26. M. R. Laurent, V. Dubois, F. Claessens et al., “Muscle-bone interactions: from experimental models to the clinic? A critical update,” Molecular and Cellular Endocrinology, vol. 432, pp. 14–36, 2016. View at Publisher · View at Google Scholar · View at Scopus
  27. H. Kaji, “Effects of myokines on bone,” BoneKEy Reports, vol. 5, article 826, 2016. View at Publisher · View at Google Scholar
  28. C. J. Smith, H. C. Emsley, C. T. Udeh et al., “Interleukin-1 receptor antagonist reverses stroke-associated peripheral immune suppression,” Cytokine, vol. 58, no. 3, pp. 384–389, 2012. View at Publisher · View at Google Scholar · View at Scopus
  29. S. K. McCann, F. Cramond, M. R. Macleod, and E. S. Sena, “Systematic review and meta-analysis of the efficacy of interleukin-1 receptor antagonist in animal models of stroke: an update,” Translational Stroke Research, vol. 7, no. 5, pp. 395–406, 2016. View at Publisher · View at Google Scholar · View at Scopus
  30. V. Banwell, E. S. Sena, and M. R. Macleod, “Systematic review and stratified meta-analysis of the efficacy of interleukin-1 receptor antagonist in animal models of stroke,” Journal of Stroke and Cerebrovascular Diseases, vol. 18, no. 4, pp. 269–276, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. A. El-Armouche, N. Ouchi, K. Tanaka et al., “Follistatin-like 1 in chronic systolic heart failure a marker of left ventricular remodeling,” Circulation: Heart Failure, vol. 4, no. 5, pp. 621–627, 2011. View at Publisher · View at Google Scholar · View at Scopus
  32. S. Hayakawa, K. Ohashi, R. Shibata et al., “Association of circulating follistatin-like 1 levels with inflammatory and oxidative stress markers in healthy men,” PLoS ONE, vol. 11, no. 5, Article ID e0153619, 2016. View at Publisher · View at Google Scholar
  33. M. Miyabe, K. Ohashi, R. Shibata et al., “Muscle-derived follistatin-like 1 functions to reduce neointimal formation after vascular injury,” Cardiovascular Research, vol. 103, no. 1, pp. 111–120, 2014. View at Publisher · View at Google Scholar · View at Scopus
  34. E. J. Duh, H. S. Yang, I. Suzuma et al., “Pigment epithelium-derived factor suppresses ischemia-induced retinal neovascularization and VEGF-induced migration and growth,” Investigative Ophthalmology and Visual Science, vol. 43, no. 3, pp. 821–829, 2002. View at Google Scholar · View at Scopus
  35. M. Ebinger, N. Ipsen, C. O. Leonards et al., “Circulating insulin-like growth factor binding protein-3 predicts one-year outcome after ischemic stroke,” Experimental and Clinical Endocrinology and Diabetes, vol. 123, no. 8, pp. 461–465, 2015. View at Publisher · View at Google Scholar · View at Scopus
  36. W. Chi, F. Meng, Y. Li et al., “Downregulation of miRNA-134 protects neural cells against ischemic injury in N2A cells and mouse brain with ischemic stroke by targeting HSPA12B,” Neuroscience, vol. 277, pp. 111–122, 2014. View at Publisher · View at Google Scholar · View at Scopus
  37. Q. Su, Y. Cheng, K. Jin et al., “Estrogen therapy increases BDNF expression and improves post-stroke depression in ovariectomy-treated rats,” Experimental and Therapeutic Medicine, vol. 12, no. 3, pp. 1843–1848, 2016. View at Publisher · View at Google Scholar · View at Scopus
  38. E. H. Kim, D. H. Kim, H. R. Kim, S. Y. Kim, H. H. Kim, and O. Y. Bang, “Stroke serum priming modulates characteristics of mesenchymal stromal cells by controlling the expression miRNA-20a,” Cell Transplantation, vol. 25, no. 8, pp. 1489–1499, 2016. View at Publisher · View at Google Scholar · View at Scopus
  39. M. B. Jensen, M. R. Chacon, J. A. Sattin, A. Aleu, and P. D. Lyden, “The promise and potential pitfalls of serum biomarkers for ischemic stroke and transient ischemic attack,” Neurologist, vol. 14, no. 4, pp. 243–246, 2008. View at Publisher · View at Google Scholar · View at Scopus
  40. G. Andsberg, Z. Kokaia, and O. Lindvall, “Upregulation of p75 neurotrophin receptor after stroke in mice does not contribute to differential vulnerability of striatal neurons,” Experimental Neurology, vol. 169, no. 2, pp. 351–363, 2001. View at Publisher · View at Google Scholar · View at Scopus
  41. S. S. Kang, M. P. Keasey, S. A. Arnold, R. Reid, J. Geralds, and T. Hagg, “Endogenous CNTF mediates stroke-induced adult CNS neurogenesis in mice,” Neurobiology of Disease, vol. 49, no. 1, pp. 68–78, 2013. View at Publisher · View at Google Scholar · View at Scopus
  42. S. S. Kang, M. P. Keasey, J. Cai, and T. Hagg, “Loss of neuron-astroglial interaction rapidly induces protective CNTF expression after stroke in mice,” Journal of Neuroscience, vol. 32, no. 27, pp. 9277–9287, 2012. View at Publisher · View at Google Scholar · View at Scopus
  43. H. Laaksovirta, S. Soinila, V. Hukkanen, M. Röyttä, and M. Soilu-Hänninen, “Serum level of CNTF is elevated in patients with amyotrophic lateral sclerosis and correlates with site of disease onset,” European Journal of Neurology, vol. 15, no. 4, pp. 355–359, 2008. View at Publisher · View at Google Scholar · View at Scopus
  44. S. S. Sørensen, A.-B. Nygaard, M.-Y. Nielsen, K. Jensen, and T. Christensen, “miRNA expression profiles in cerebrospinal fluid and blood of patients with acute ischemic stroke,” Translational Stroke Research, vol. 5, no. 6, pp. 711–718, 2014. View at Publisher · View at Google Scholar · View at Scopus
  45. X.-F. Fu, X. Zhang, D.-J. Wang, B. Zhao, and Y.-R. Li, “Neuropeptide Y gene promoter -399T/C polymorphism increases risk of ischemic stroke,” Balkan Medical Journal, vol. 30, no. 2, pp. 147–150, 2013. View at Publisher · View at Google Scholar · View at Scopus
  46. C. Rink and S. Khanna, “MicroRNA in ischemic stroke etiology and pathology,” Physiological Genomics, vol. 43, no. 10, pp. 521–528, 2011. View at Publisher · View at Google Scholar · View at Scopus
  47. G. L. Santos, C. C. Alcântara, M. A. Silva-Couto, L. F. García-Salazar, and T. L. Russo, “Decreased brain-derived neurotrophic factor serum concentrations in chronic post-stroke subjects,” Journal of Stroke and Cerebrovascular Diseases, vol. 25, no. 12, pp. 2968–2974, 2016. View at Publisher · View at Google Scholar
  48. A. Alhusban, A. Y. Fouda, and S. C. Fagan, “ARBs improve stroke outcome through an AT2-dependent, BDNF-induced proangiogenic and pro-recovery response,” Neural Regeneration Research, vol. 11, no. 6, pp. 912–913, 2016. View at Publisher · View at Google Scholar · View at Scopus
  49. D. Pasarica, M. Gheorghiu, F. Topârceanu, C. Bleotu, L. Ichim, and T. Trandafir, “Neurotrophin-3, TNF-alpha and IL-6 relations in serum and cerebrospinal fluid of ischemic stroke patients,” Roumanian Archives of Microbiology and Immunology, vol. 64, no. 1–4, pp. 27–33, 2005. View at Google Scholar · View at Scopus
  50. J. Ren and P. Anversa, “The insulin-like growth factor I system: physiological and pathophysiological implication in cardiovascular diseases associated with metabolic syndrome,” Biochemical Pharmacology, vol. 93, no. 4, pp. 409–417, 2015. View at Publisher · View at Google Scholar · View at Scopus
  51. M. I. Mohamad and M. S. Khater, “Evaluation of insulin like growth factor-1 (IGF-1) level and its impact on muscle and bone mineral density in frail elderly male,” Archives of Gerontology and Geriatrics, vol. 60, no. 1, pp. 124–127, 2015. View at Publisher · View at Google Scholar · View at Scopus
  52. R. Kooijman, S. Sarre, Y. Michotte, and J. D. Keyser, “Insulin-like growth factor I: a potential neuroprotective compound for the treatment of acute ischemic stroke?” Stroke, vol. 40, no. 4, pp. e83–e88, 2009. View at Publisher · View at Google Scholar · View at Scopus
  53. M. Niimi, K. Hashimoto, W. Kakuda et al., “Role of brain-derived neurotrophic factor in beneficial effects of repetitive transcranial magnetic stimulation for upper limb hemiparesis after stroke,” PLoS ONE, vol. 11, no. 3, Article ID e0152241, 2016. View at Publisher · View at Google Scholar · View at Scopus
  54. X.-L. Chen, B.-J. Yu, and M.-H. Chen, “Circulating levels of neuropeptide proenkephalin A predict outcome in patients with aneurysmal subarachnoid hemorrhage,” Peptides, vol. 56, pp. 111–115, 2014. View at Publisher · View at Google Scholar · View at Scopus
  55. C. Iadecola and J. Anrather, “The immunology of stroke: from mechanisms to translation,” Nature Medicine, vol. 17, no. 7, pp. 796–808, 2011. View at Publisher · View at Google Scholar · View at Scopus
  56. F. Miró-Mur, X. Urra, M. Gallizioli, A. Chamorro, and A. M. Planas, “Antigen presentation after stroke,” Neurotherapeutics, vol. 13, no. 4, pp. 719–728, 2016. View at Publisher · View at Google Scholar · View at Scopus
  57. A. Lasek-Bal, H. Jędrzejowska-Szypułka, J. Różycka et al., “Low concentration of BDNF in the acute phase of ischemic stroke as a factor in poor prognosis in terms of functional status of patients,” Medical Science Monitor, vol. 21, pp. 3900–3905, 2015. View at Publisher · View at Google Scholar · View at Scopus
  58. N. Himi, H. Takahashi, N. Okabe et al., “Exercise in the early stage after stroke enhances hippocampal brain-derived neurotrophic factor expression and memory function recovery,” Journal of Stroke and Cerebrovascular Diseases, vol. 25, no. 12, pp. 2987–2994, 2016. View at Publisher · View at Google Scholar
  59. X. Li, W. Zheng, H. Bai et al., “Intravenous administration of adipose tissue-derived stem cells enhances nerve healing and promotes BDNF expression via the TrkB signaling in a rat stroke model,” Neuropsychiatric Disease and Treatment, vol. 12, pp. 1287–1293, 2016. View at Publisher · View at Google Scholar · View at Scopus
  60. R. Verma, N. M. Harris, B. D. Friedler et al., “Reversal of the detrimental effects of post-stroke social isolation by pair-housing is mediated by activation of BDNF-MAPK/ERK in aged mice,” Scientific Reports, vol. 6, Article ID 25176, 2016. View at Publisher · View at Google Scholar · View at Scopus
  61. V. R. Venna and L. D. McCullough, “Role of social factors on cell death, cerebral plasticity and recovery after stroke,” Metabolic Brain Disease, vol. 30, no. 2, pp. 497–506, 2015. View at Publisher · View at Google Scholar · View at Scopus
  62. J. Lu, Y. Xu, W. Hu et al., “Exercise ameliorates depression-like behavior and increases hippocampal BDNF level in ovariectomized rats,” Neuroscience Letters, vol. 573, pp. 13–18, 2014. View at Publisher · View at Google Scholar · View at Scopus
  63. A. Pikula, A. S. Beiser, T. C. Chen et al., “Serum brain-derived neurotrophic factor and vascular endothelial growth factor levels are associated with risk of stroke and vascular brain injury framingham study,” Stroke, vol. 44, no. 10, pp. 2768–2775, 2013. View at Publisher · View at Google Scholar · View at Scopus
  64. A. Pikula, A. S. Beiser, C. Decarli et al., “Multiple biomarkers and risk of clinical and subclinical vascular brain injury: the framingham offspring study,” Circulation, vol. 125, no. 17, pp. 2100–2107, 2012. View at Publisher · View at Google Scholar · View at Scopus
  65. J.-Y. Chung, M.-W. Kim, M.-S. Bang, and M. Kim, “Increased expression of neurotrophin 4 following focal cerebral ischemia in adult rat brain with treadmill exercise,” PLOS ONE, vol. 8, no. 3, Article ID e52461, 2013. View at Publisher · View at Google Scholar · View at Scopus
  66. W. Doehner, S. Von Haehling, J. Suhr et al., “Elevated plasma levels of neuropeptide proenkephalin a predict mortality and functional outcome in ischemic stroke,” Journal of the American College of Cardiology, vol. 60, no. 4, pp. 346–354, 2012. View at Publisher · View at Google Scholar · View at Scopus
  67. W. Whiteley, W. L. Chong, A. Sengupta, and P. Sandercock, “Blood markers for the prognosis of ischemic stroke: a systematic review,” Stroke, vol. 40, no. 5, pp. e380–e389, 2009. View at Publisher · View at Google Scholar · View at Scopus
  68. M. Matsumoto, T. Nakamachi, J. Watanabe et al., “Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) is involved in adult mouse hippocampal neurogenesis after stroke,” Journal of Molecular Neuroscience, vol. 59, no. 2, pp. 270–279, 2016. View at Publisher · View at Google Scholar · View at Scopus
  69. B.-Q. Ma, M. Zhang, and L. Ba, “Plasma pituitary adenylate cyclase-activating polypeptide concentrations and mortality after acute spontaneous basal ganglia hemorrhage,” Clinica Chimica Acta, vol. 439, pp. 102–106, 2015. View at Publisher · View at Google Scholar · View at Scopus
  70. O. Aze, É. Odjardias, X. Devillard, B. Akplogan, P. Calmels, and P. Giraux, “Structural and physiological muscle changes after post-stroke hemiplegia: a systematic review,” Annals of Physical and Rehabilitation Medicine, vol. 59, article e79, 2016. View at Publisher · View at Google Scholar
  71. G. Colaianni, T. Mongelli, S. Colucci, S. Cinti, and M. Grano, “Crosstalk between muscle and bone via the muscle-myokine irisin,” Current Osteoporosis Reports, vol. 14, no. 4, pp. 132–137, 2016. View at Publisher · View at Google Scholar · View at Scopus
  72. B. K. Pedersen and C. Brandt, “The role of exercise-induced myokines in muscle homeostasis and the defense against chronic diseases,” Journal of Biomedicine and Biotechnology, vol. 2010, Article ID 520258, 6 pages, 2010. View at Publisher · View at Google Scholar · View at Scopus
  73. D. Di Raimondo, A. Tuttolomondo, G. Musiari, C. Schimmenti, A. D’Angelo, and A. Pinto, “Are the myokines the mediators of physical activity-induced health benefits?” Current Pharmaceutical Design, vol. 22, no. 24, pp. 3622–3647, 2016. View at Publisher · View at Google Scholar · View at Scopus
  74. P. Boström, J. Wu, M. P. Jedrychowski et al., “A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis,” Nature, vol. 481, no. 7382, pp. 463–468, 2012. View at Publisher · View at Google Scholar · View at Scopus
  75. Y. Tsuchiya, T. Ijichi, and K. Goto, “Effect of sprint training on resting serum irisin concentration—sprint training once daily vs. twice every other day,” Metabolism: Clinical and Experimental, vol. 65, no. 4, pp. 492–495, 2016. View at Publisher · View at Google Scholar · View at Scopus
  76. Y. Lu, H. Li, S. Shen et al., “Swimming exercise increases serum irisin level and reduces body fat mass in high-fat-diet fed Wistar rats,” Lipids in Health and Disease, vol. 15, no. 1, article no. 93, 2016. View at Publisher · View at Google Scholar
  77. S. H. Lecker, A. Zavin, P. Cao et al., “Expression of the irisin precursor FNDC5 in skeletal muscle correlates with aerobic exercise performance in patients with heart failure,” Circulation: Heart Failure, vol. 5, no. 6, pp. 812–818, 2012. View at Publisher · View at Google Scholar · View at Scopus
  78. J. Prestes, D. da Cunha Nascimento, R. A. Tibana et al., “Understanding the individual responsiveness to resistance training periodization,” Age, vol. 37, no. 3, article no. 55, 2015. View at Publisher · View at Google Scholar · View at Scopus
  79. C. D. Wrann, J. P. White, J. Salogiannnis et al., “Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway,” Cell Metabolism, vol. 18, no. 5, pp. 649–659, 2013. View at Publisher · View at Google Scholar · View at Scopus
  80. B. Xu, “BDNF (I)rising from exercise,” Cell Metabolism, vol. 18, no. 5, pp. 612–614, 2013. View at Publisher · View at Google Scholar · View at Scopus
  81. S. Vaynman, Z. Ying, and F. Gómez-Pinilla, “Exercise induces BDNF and synapsin I to specific hippocampal subfields,” Journal of Neuroscience Research, vol. 76, no. 3, pp. 356–362, 2004. View at Publisher · View at Google Scholar · View at Scopus
  82. G. Leal, D. Comprido, and C. B. Duarte, “BDNF-induced local protein synthesis and synaptic plasticity,” Neuropharmacology, vol. 76, pp. 639–656, 2014. View at Publisher · View at Google Scholar · View at Scopus
  83. C. Jiang, W. Kong, Y. Wang et al., “Changes in the cellular immune system and circulating inflammatory markers of stroke patients,” Oncotarget, vol. 8, no. 2, pp. 3553–3567, 2017. View at Publisher · View at Google Scholar
  84. Z. H. Cheung, W. H. Chin, Y. Chen, Y. P. Ng, and N. Y. Ip, “Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons,” PLoS Biology, vol. 5, no. 4, article e63, 2007. View at Publisher · View at Google Scholar · View at Scopus
  85. G. N. Ruegsegger, R. G. Toedebusch, T. E. Childs, K. B. Grigsby, and F. W. Booth, “Loss of Cdk5 function in the nucleus accumbens decreases wheel running and may mediate age-related declines in voluntary physical activity,” The Journal of Physiology, vol. 595, no. 1, pp. 363–384, 2017. View at Publisher · View at Google Scholar
  86. J. Zsuga, G. Tajti, C. Papp, B. Juhasz, and R. Gesztelyi, “FNDC5/irisin, a molecular target for boosting reward-related learning and motivation,” Medical Hypotheses, vol. 90, pp. 23–28, 2016. View at Publisher · View at Google Scholar · View at Scopus
  87. A. Maddahi and L. Edvinsson, “Cerebral ischemia induces microvascular pro-inflammatory cytokine expression via the MEK/ERK pathway,” Journal of Neuroinflammation, vol. 7, article 14, 2010. View at Publisher · View at Google Scholar · View at Scopus
  88. A. S. Ryan, F. M. Ivey, S. Prior, G. Li, and C. Hafer-Macko, “Skeletal muscle hypertrophy and muscle myostatin reduction after resistive training in stroke survivors,” Stroke, vol. 42, no. 2, pp. 416–420, 2011. View at Publisher · View at Google Scholar · View at Scopus
  89. D.-S. Han, Y.-M. Chen, S.-Y. Lin et al., “Serum myostatin levels and grip strength in normal subjects and patients on maintenance haemodialysis,” Clinical Endocrinology, vol. 75, no. 6, pp. 857–863, 2011. View at Publisher · View at Google Scholar · View at Scopus
  90. C.-R. Ju and R.-C. Chen, “Serum myostatin levels and skeletal muscle wasting in chronic obstructive pulmonary disease,” Respiratory Medicine, vol. 106, no. 1, pp. 102–108, 2012. View at Publisher · View at Google Scholar · View at Scopus
  91. X. Ge, D. Sathiakumar, B. J. G. Lua, H. Kukreti, M. Lee, and C. McFarlane, “Myostatin signals through miR-34a to regulate Fndc5 expression and browning of white adipocytes,” International Journal of Obesity, vol. 41, pp. 137–148, 2017. View at Publisher · View at Google Scholar · View at Scopus
  92. J. Y. Huh, F. Dincer, E. Mesfum, and C. S. Mantzoros, “Irisin stimulates muscle growth-related genes and regulates adipocyte differentiation and metabolism in humans,” International Journal of Obesity, vol. 38, no. 12, pp. 1538–1544, 2014. View at Publisher · View at Google Scholar · View at Scopus
  93. M. Foroughi, M. Akhavanzanjani, Z. Maghsoudi, R. Ghiasvand, F. Khorvash, and G. Askari, “Stroke and nutrition: a review of studies,” International Journal of Preventive Medicine, vol. 4, pp. S165–S179, 2013. View at Google Scholar · View at Scopus
  94. E. Castillero, H. Akashi, C. Wang et al., “Cardiac myostatin upregulation occurs immediately after myocardial ischemia and is involved in skeletal muscle activation of atrophy,” Biochemical and Biophysical Research Communications, vol. 457, no. 1, pp. 106–111, 2015. View at Publisher · View at Google Scholar · View at Scopus
  95. B. Feng, W. Wu, H. Wang, J. Wang, D. Huang, and L. Cheng, “Interaction between muscle and bone, and improving the effects of electrical muscle stimulation on amyotrophy and bone loss in a denervation rat model via sciatic neurectomy,” Biomedical Reports, vol. 4, no. 5, pp. 589–594, 2016. View at Publisher · View at Google Scholar
  96. M. M. Desgeorges, X. Devillard, J. Toutain et al., “Molecular mechanisms of skeletal muscle atrophy in a mouse model of cerebral ischemia,” Stroke, vol. 46, no. 6, pp. 1673–1680, 2015. View at Publisher · View at Google Scholar · View at Scopus
  97. G. Lombardi, F. Sanchis-Gomar, S. Perego, V. Sansoni, and G. Banfi, “Implications of exercise-induced adipo-myokines in bone metabolism,” Endocrine, vol. 54, no. 2, pp. 284–305, 2016. View at Publisher · View at Google Scholar · View at Scopus
  98. G. Morris, M. Berk, P. Galecki, K. Walder, and M. Maes, “The neuro-immune pathophysiology of central and peripheral fatigue in systemic immune-inflammatory and neuro-immune diseases,” Molecular Neurobiology, vol. 53, no. 2, pp. 1195–1219, 2016. View at Publisher · View at Google Scholar · View at Scopus
  99. H. Manso, T. Krug, J. Sobral et al., “Variants in the inflammatory IL6 and MPO genes modulate stroke susceptibility through main effects and gene-gene interactions,” Journal of Cerebral Blood Flow and Metabolism, vol. 31, no. 8, pp. 1751–1759, 2011. View at Publisher · View at Google Scholar · View at Scopus
  100. S. S. Welc, T. L. Clanton, S. M. Dineen, and L. R. Leon, “Heat stroke activates a stress-induced cytokine response in skeletal muscle,” Journal of Applied Physiology, vol. 115, no. 8, pp. 1126–1137, 2013. View at Publisher · View at Google Scholar · View at Scopus
  101. S. Gielen, V. Adams, S. Möbius-Winkler et al., “Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure,” Journal of the American College of Cardiology, vol. 42, no. 5, pp. 861–868, 2003. View at Publisher · View at Google Scholar · View at Scopus
  102. D. E. Forman, K. M. Daniels, L. P. Cahalin et al., “Analysis of skeletal muscle gene expression patterns and the impact of functional capacity in patients with systolic heart failure,” Journal of Cardiac Failure, vol. 20, no. 6, pp. 422–430, 2014. View at Publisher · View at Google Scholar · View at Scopus
  103. C. Jiang, W. Kong, Y. Wang et al., “Changes in the cellular immune system and circulating inflammatory markers of stroke patients,” Oncotarget, 2016. View at Publisher · View at Google Scholar
  104. Z. Su, L. Hu, J. Cheng et al., “Acupuncture plus low-frequency electrical stimulation (Acu-LFES) attenuates denervation-induced muscle atrophy,” Journal of Applied Physiology, vol. 120, no. 4, pp. 426–436, 2016. View at Publisher · View at Google Scholar · View at Scopus
  105. Z. Su, A. Robinson, L. Hu et al., “Acupuncture plus low-frequency electrical stimulation (Acu-LFES) attenuates diabetic myopathy by enhancing muscle regeneration,” PLOS ONE, vol. 10, no. 7, Article ID e0134511, 2015. View at Publisher · View at Google Scholar · View at Scopus
  106. C. Kang and L. Li Ji, “Role of PGC-1α signaling in skeletal muscle health and disease,” Annals of the New York Academy of Sciences, vol. 1271, no. 1, pp. 110–117, 2012. View at Publisher · View at Google Scholar · View at Scopus
  107. A. Vainshtein and D. A. Hood, “The regulation of autophagy during exercise in skeletal muscle,” Journal of Applied Physiology, vol. 120, no. 6, pp. 664–673, 2016. View at Publisher · View at Google Scholar
  108. P. A. Grimaldi, “Roles of PPARδ in the control of muscle development and metabolism,” Biochemical Society Transactions, vol. 31, no. 6, pp. 1130–1132, 2003. View at Publisher · View at Google Scholar · View at Scopus
  109. W. J. Smiles, E. B. Parr, V. G. Coffey, O. Lacham-Kaplan, J. A. Hawley, and D. M. Camera, “Protein coingestion with alcohol following strenuous exercise attenuates alcohol-induced intramyocellular apoptosis and inhibition of autophagy,” American Journal of Physiology—Endocrinology And Metabolism, vol. 311, no. 5, pp. E836–E849, 2016. View at Publisher · View at Google Scholar
  110. A. Botta, I. Laher, J. Beam et al., “Short term exercise induces PGC-1α, ameliorates inflammation and increases mitochondrial membrane proteins but fails to increase respiratory enzymes in aging diabetic hearts,” PLoS ONE, vol. 8, no. 8, Article ID e70248, 2013. View at Publisher · View at Google Scholar · View at Scopus
  111. M. J. Abbott, J. E. Krolopp, S. M. Thornton, and A. Kawata, “PPARδ is required For IL-15-induced mitochondrial activity in C2C12 skeletal muscle cells,” Medicine & Science in Sports & Exercise, vol. 48, no. 5, supplement 1, p. 544, 2016. View at Publisher · View at Google Scholar
  112. M. Molanouri Shamsi, Z. H. Hassan, R. Gharakhanlou et al., “Expression of interleukin-15 and inflammatory cytokines in skeletal muscles of STZ-induced diabetic rats: effect of resistance exercise training,” Endocrine, vol. 46, no. 1, pp. 60–69, 2014. View at Publisher · View at Google Scholar · View at Scopus
  113. H. C. Kim, H.-Y. Cho, and Y.-S. Hah, “Role of IL-15 in sepsis-induced skeletal muscle atrophy and proteolysis,” Tuberculosis and Respiratory Diseases, vol. 73, no. 6, pp. 312–319, 2012. View at Publisher · View at Google Scholar · View at Scopus
  114. W. Xie, L. Fang, S. Gan, and H. Xuan, “Interleukin-19 alleviates brain injury by anti-inflammatory effects in a mice model of focal cerebral ischemia,” Brain Research, vol. 1650, pp. 172–177, 2016. View at Publisher · View at Google Scholar
  115. P. Korhonen, K. M. Kanninen, Š. Lehtonen et al., “Immunomodulation by interleukin-33 is protective in stroke through modulation of inflammation,” Brain, Behavior, and Immunity, vol. 49, pp. 322–336, 2015. View at Publisher · View at Google Scholar · View at Scopus
  116. M. J. Drummond, K. L. Timmerman, M. M. Markofski et al., “Short-term bed rest increases TLR4 and IL-6 expression in skeletal muscle of older adults,” American Journal of Physiology—Regulatory Integrative and Comparative Physiology, vol. 305, no. 3, pp. R216–R223, 2013. View at Publisher · View at Google Scholar · View at Scopus
  117. S. E. Conway, M. Roy-O'Reilly, B. Friedler, I. Staff, G. Fortunato, and L. D. McCullough, “Sex differences and the role of IL-10 in ischemic stroke recovery,” Biology of Sex Differences, vol. 6, article 17, 2015. View at Publisher · View at Google Scholar · View at Scopus
  118. W. He, H. Song, L. Ding, C. Li, L. Dai, and S. Gao, “Association between IL-10 gene polymorphisms and the risk of ischemic stroke in a Chinese population,” International Journal of Clinical and Experimental Pathology, vol. 8, no. 10, pp. 13489–13494, 2015. View at Google Scholar
  119. S. P. M. Janssen, G. Gayan-Ramirez, A. Van Den Bergh et al., “Interleukin-6 causes myocardial failure and skeletal muscle atrophy in rats,” Circulation, vol. 111, no. 8, pp. 996–1005, 2005. View at Publisher · View at Google Scholar · View at Scopus
  120. L. Pelosi, M. G. Berardinelli, L. De Pasquale et al., “Functional and morphological improvement of dystrophic muscle by interleukin 6 receptor blockade,” EBioMedicine, vol. 2, no. 4, pp. 285–293, 2015. View at Publisher · View at Google Scholar · View at Scopus
  121. M. A. Alam, V. P. Subramanyam Rallabandi, and P. K. Roy, “Systems biology of immunomodulation for post-stroke neuroplasticity: multimodal implications of pharmacotherapy and neurorehabilitation,” Frontiers in Neurology, vol. 7, article 94, 2016. View at Publisher · View at Google Scholar · View at Scopus
  122. Y. Lin, J. C. Zhang, C. Y. Yao et al., “Critical role of astrocytic interleukin-17 A in post-stroke survival and neuronal differentiation of neural precursor cells in adult mice,” Cell Death and Disease, vol. 7, no. 6, Article ID e2273, 2016. View at Publisher · View at Google Scholar
  123. K. Kanda, K. Sugama, J. Sakuma, Y. Kawakami, and K. Suzuki, “Evaluation of serum leaking enzymes and investigation into new biomarkers for exerciseinduced muscle damage,” Exercise Immunology Review, vol. 20, pp. 39–54, 2014. View at Google Scholar · View at Scopus
  124. J. M. Peake, P. D. Gatta, K. Suzuki, and D. C. Nieman, “Cytokine expression and secretion by skeletal muscle cells: regulatory mechanisms and exercise effects,” Exercise Immunology Review, vol. 21, pp. 8–25, 2015. View at Google Scholar · View at Scopus
  125. R. H. Wu, P. Wang, L. Yang, Y. Li, Y. Liu, and M. Liu, “A potential indicator of denervated muscle atrophy: the ratio of myostatin to follistatin in peripheral blood,” Genetics and Molecular Research, vol. 10, no. 4, pp. 3914–3923, 2011. View at Publisher · View at Google Scholar · View at Scopus
  126. A. D. Anastasilakis, S. A. Polyzos, E. C. Skouvaklidou et al., “Circulating follistatin displays a day-night rhythm and is associated with muscle mass and circulating leptin levels in healthy, young humans,” Metabolism, vol. 65, no. 10, pp. 1459–1465, 2016. View at Google Scholar
  127. S. Raschke, K. Eckardt, K. Bjørklund Holven, J. Jensen, and J. Eckel, “Identification and validation of novel contraction-regulated myokines released from primary human skeletal muscle cells,” PLoS ONE, vol. 8, no. 4, Article ID e62008, 2013. View at Publisher · View at Google Scholar · View at Scopus
  128. M. Catoire, M. Mensink, E. Kalkhoven, P. Schrauwen, and S. Kersten, “Identification of human exercise-induced myokines using secretome analysis,” Physiological Genomics, vol. 46, no. 7, pp. 256–267, 2014. View at Publisher · View at Google Scholar · View at Scopus
  129. N. Ouchi, Y. Oshima, K. Ohashi et al., “Follistatin-like 1, a secreted muscle protein, promotes endothelial cell function and revascularization in ischemic tissue through a nitric-oxide synthase-dependent mechanism,” Journal of Biological Chemistry, vol. 283, no. 47, pp. 32802–32811, 2008. View at Publisher · View at Google Scholar · View at Scopus
  130. Y. Chaly, B. Hostager, S. Smith, and R. Hirsch, “Follistatin-like protein 1 and its role in inflammation and inflammatory diseases,” Immunologic Research, vol. 59, no. 1–3, pp. 266–272, 2014. View at Publisher · View at Google Scholar · View at Scopus
  131. S. Raschke and J. Eckel, “Adipo-myokines: two sides of the same coin—mediators of inflammation and mediators of exercise,” Mediators of Inflammation, vol. 2013, Article ID 320724, 16 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  132. X. Liang, Q. Hu, B. Li et al., “Follistatin-like 1 attenuates apoptosis via disco-interacting protein 2 homolog A/Akt pathway after middle cerebral artery occlusion in rats,” Stroke, vol. 45, no. 10, pp. 3048–3054, 2014. View at Publisher · View at Google Scholar · View at Scopus
  133. N. Ouchi, Y. Asaumi, K. Ohashi et al., “DIP2A functions as a FSTL1 receptor,” Journal of Biological Chemistry, vol. 285, no. 10, pp. 7127–7134, 2010. View at Publisher · View at Google Scholar · View at Scopus
  134. Y. Xi, D.-W. Gong, and Z. Tian, “FSTL1 as a potential mediator of exercise-induced cardioprotection in post-myocardial infarction rats,” Scientific Reports, vol. 6, Article ID 32424, 2016. View at Publisher · View at Google Scholar · View at Scopus
  135. M. Zille, A. Riabinska, M. Y. Terzi et al., “Influence of pigment epithelium-derived factor on outcome after striatal cerebral ischemia in the mouse,” PLoS ONE, vol. 9, no. 12, Article ID e114595, 2014. View at Publisher · View at Google Scholar · View at Scopus
  136. A. Takanohashi, T. Yabe, and J. P. Schwartz, “Pigment epithelium-derived factor induces the production of chemokines by rat microglia,” GLIA, vol. 51, no. 4, pp. 266–278, 2005. View at Publisher · View at Google Scholar · View at Scopus
  137. V. Darsalia, M. Larsson, D. Nathanson, T. Klein, T. Nyström, and C. Patrone, “Glucagon-like receptor 1 agonists and DPP-4 inhibitors: potential therapies for the treatment of stroke,” Journal of Cerebral Blood Flow and Metabolism, vol. 35, no. 5, pp. 718–723, 2015. View at Publisher · View at Google Scholar · View at Scopus
  138. K. Tziomalos, S. D. Bouziana, M. Spanou et al., “Prior treatment with dipeptidyl peptidase 4 inhibitors is associated with better functional outcome and lower in-hospital mortality in patients with type 2 diabetes mellitus admitted with acute ischaemic stroke,” Diabetes and Vascular Disease Research, vol. 12, no. 6, pp. 463–466, 2015. View at Publisher · View at Google Scholar · View at Scopus
  139. M. DeNicola, J. Du, Z. Wang et al., “Stimulation of glucagon-like peptide-1 receptor through exendin-4 preserves myocardial performance and prevents cardiac remodeling in infarcted myocardium,” American Journal of Physiology—Endocrinology and Metabolism, vol. 307, no. 8, pp. E630–E643, 2014. View at Publisher · View at Google Scholar · View at Scopus
  140. S. Takada, Y. Masaki, S. Kinugawa et al., “Dipeptidyl peptidase-4 inhibitor improved exercise capacity and mitochondrial biogenesis in mice with heart failure via activation of glucagon-like peptide-1 receptor signalling,” Cardiovascular Research, vol. 111, no. 4, pp. 338–347, 2016. View at Publisher · View at Google Scholar
  141. T. Karagiannis, P. Paschos, K. Paletas, D. R. Matthews, and A. Tsapas, “Dipeptidyl peptidase-4 inhibitors for treatment of type 2 diabetes mellitus in the clinical setting: systematic review and meta-analysis,” BMJ, vol. 344, no. 7850, Article ID e1369, 2012. View at Publisher · View at Google Scholar · View at Scopus
  142. H. Lee, H. Chang, S. Lee et al., “Role of IGF1R+ MSCs in modulating neuroplasticity via CXCR4 cross-interaction,” Scientific Reports, vol. 6, Article ID 32595, 2016. View at Publisher · View at Google Scholar
  143. H. K. Haider, S. Jiang, N. M. Idris, and M. Ashraf, “IGF-1—overexpressing mesenchymal stem cells accelerate bone marrow stem cell mobilization via paracrine activation of SDF-1α/CXCR4 signaling to promote myocardial repair,” Circulation Research, vol. 103, no. 11, pp. 1300–1308, 2008. View at Publisher · View at Google Scholar · View at Scopus
  144. A. Arnarson, O. G. Geirsdottir, A. Ramel, P. V. Jonsson, and I. Thorsdottir, “Insulin-like growth factor-1 and resistance exercise in community dwelling old adults,” Journal of Nutrition, Health and Aging, vol. 19, no. 8, pp. 856–860, 2015. View at Publisher · View at Google Scholar · View at Scopus
  145. M. Ploughman, M. W. Austin, L. Glynn, and D. Corbett, “The effects of poststroke aerobic exercise on neuroplasticity: a systematic review of animal and clinical studies,” Translational Stroke Research, vol. 6, no. 1, pp. 13–28, 2015. View at Publisher · View at Google Scholar · View at Scopus
  146. C. S. Mang, K. L. Campbell, C. J. D. Ross, and L. A. Boyd, “Promoting neuroplasticity for motor rehabilitation after stroke: considering the effects of aerobic exercise and genetic variation on brain-derived neurotrophic factor,” Physical Therapy, vol. 93, no. 12, pp. 1707–1716, 2013. View at Publisher · View at Google Scholar · View at Scopus
  147. J. Li, Y. Tang, Y. Wang et al., “Neurovascular recovery via cotransplanted neural and vascular progenitors leads to improved functional restoration after ischemic stroke in rats,” Stem Cell Reports, vol. 3, no. 1, pp. 101–114, 2014. View at Publisher · View at Google Scholar · View at Scopus
  148. X. Cui, M. Chopp, A. Zacharek et al., “D-4F decreases white matter damage after stroke in mice,” Stroke, vol. 47, no. 1, pp. 214–220, 2016. View at Publisher · View at Google Scholar · View at Scopus
  149. H. Okazaki, H. Beppu, K. Mizutani, S. Okamoto, and S. Sonoda, “Changes in serum growth factors in stroke rehabilitation patients and their relation to hemiparesis improvement,” Journal of Stroke and Cerebrovascular Diseases, vol. 23, no. 6, pp. 1703–1708, 2014. View at Publisher · View at Google Scholar · View at Scopus
  150. A. E. Mattlage, M. A. Rippee, J. Sandt, and S. A. Billinger, “Decrease in insulin-like growth factor-1 and insulin-like growth factor-1 ratio in the first week of stroke is related to positive outcomes,” Journal of Stroke and Cerebrovascular Diseases, vol. 25, no. 7, pp. 1800–1806, 2016. View at Publisher · View at Google Scholar · View at Scopus
  151. S. P. Johnsen, H. H. Hundborg, H. T. Sørensen et al., “Insulin-like growth factor (IGF) I, -II, and IGF binding protein-3 and risk of ischemic stroke,” Journal of Clinical Endocrinology and Metabolism, vol. 90, no. 11, pp. 5937–5941, 2005. View at Publisher · View at Google Scholar · View at Scopus
  152. R. C. Kaplan, A. P. McGinn, M. N. Pollak et al., “Association of total insulin-like growth factor-I, insulin-like growth factor binding protein-1 (IGFBP-1), and IGFBP-3 levels with incident coronary events and ischemic stroke,” Journal of Clinical Endocrinology and Metabolism, vol. 92, no. 4, pp. 1319–1325, 2007. View at Publisher · View at Google Scholar · View at Scopus
  153. Y. Xiao, L. Liu, A. Xu et al., “Serum fibroblast growth factor 21 levels are related to subclinical atherosclerosis in patients with type 2 diabetes,” Cardiovascular Diabetology, vol. 14, article 72, 2015. View at Publisher · View at Google Scholar · View at Scopus
  154. E. Lovadi, M. Csereklyei, H. Merkli et al., “Elevated FGF 21 in myotonic dystrophy type 1 and mitochondrial diseases,” Muscle & Nerve, 2016. View at Publisher · View at Google Scholar
  155. X. Wang, H. Xiao, L. Liu, D. Cheng, X. Li, and L. Si, “FGF21 represses cerebrovascular aging via improving mitochondrial biogenesis and inhibiting p53 signaling pathway in an AMPK-dependent manner,” Experimental Cell Research, vol. 346, no. 2, pp. 147–156, 2016. View at Publisher · View at Google Scholar
  156. P. Lee, J. Linderman, S. Smith et al., “Fibroblast growth factor 21 (FGF21) and bone: is there a relationship in humans?” Osteoporosis International, vol. 24, no. 12, pp. 3053–3057, 2013. View at Publisher · View at Google Scholar · View at Scopus
  157. X. Li, S. Stanislaus, F. Asuncion et al., “FGF21 is not a major mediator for bone homeostasis or metabolic actions of PPARα and PPARγ agonists,” Journal of Bone and Mineral Research, 2016. View at Publisher · View at Google Scholar
  158. C. Loyd, I. J. Magrisso, M. Haas et al., “Fibroblast growth factor 21 is required for beneficial effects of exercise during chronic high-fat feeding,” Journal of Applied Physiology, vol. 121, no. 3, pp. 687–698, 2016. View at Publisher · View at Google Scholar
  159. X. Xu and Y. Jiang, “The yin and yang of innate immunity in stroke,” BioMed Research International, vol. 2014, Article ID 807978, 8 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  160. D. Petrovic-Djergovic, S. N. Goonewardena, and D. J. Pinsky, “Inflammatory disequilibrium in stroke,” Circulation Research, vol. 119, no. 1, pp. 142–158, 2016. View at Publisher · View at Google Scholar · View at Scopus
  161. J. H. Tapia-Pérez, D. Karagianis, R. Zilke, V. Koufuglou, I. Bondar, and T. Schneider, “Assessment of systemic cellular inflammatory response after spontaneous intracerebral hemorrhage,” Clinical Neurology and Neurosurgery, vol. 150, pp. 72–79, 2016. View at Publisher · View at Google Scholar
  162. H.-Y. Fang, W.-J. Ko, and C.-Y. Lin, “Plasma interleukin 11 levels correlate with outcome of spontaneous intracerebral hemorrhage,” Surgical Neurology, vol. 64, no. 6, pp. 511–517, 2005. View at Publisher · View at Google Scholar · View at Scopus
  163. A. Tuttolomondo, D. Di Raimondo, R. di Sciacca, A. Pinto, and G. Licata, “Inflammatory cytokines in acute ischemic stroke,” Current Pharmaceutical Design, vol. 14, no. 33, pp. 3574–3589, 2008. View at Publisher · View at Google Scholar · View at Scopus
  164. A. Tuttolomondo, D. Di Raimondo, R. Pecoraro, V. Arnao, A. Pinto, and G. Licata, “Inflammation in ischemic stroke subtypes,” Current Pharmaceutical Design, vol. 18, no. 28, pp. 4289–4310, 2012. View at Publisher · View at Google Scholar · View at Scopus
  165. X. Chen, Y. Wang, M. Fu, H. Lei, Q. Cheng, and X. Zhang, “Plasma immunoproteasome predicts early hemorrhagic transformation in acute ischemic stroke patients,” Journal of Stroke and Cerebrovascular Diseases, vol. 26, no. 1, pp. 49–56, 2017. View at Publisher · View at Google Scholar
  166. A. Tuttolomondo, R. Pecoraro, A. Casuccio et al., “Peripheral frequency of CD4+ CD28-cells in acute ischemic stroke relationship with stroke subtype and severity markers,” Medicine (Baltimore), vol. 94, no. 20, article no. e813, 2015. View at Publisher · View at Google Scholar · View at Scopus
  167. Z. G. Nadareishvili, H. Li, V. Wright et al., “Elevated pro-inflammatory CD4+CD28- lymphocytes and stroke recurrence and death,” Neurology, vol. 63, no. 8, pp. 1446–1451, 2004. View at Publisher · View at Google Scholar · View at Scopus
  168. S. Chen, H. Wu, D. Klebe, Y. Hong, J. Zhang, and J. Tang, “Regulatory T cell in stroke: a new paradigm for immune regulation,” Clinical and Developmental Immunology, vol. 2013, Article ID 689827, 9 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  169. P. Li, L. Mao, X. Liu et al., “Essential role of program death 1-ligand 1 in regulatory T-cell–afforded protection against blood–brain barrier damage after stroke,” Stroke, vol. 45, no. 3, pp. 857–864, 2014. View at Publisher · View at Google Scholar · View at Scopus
  170. Y. Xia, W. Cai, A. W. Thomson, and X. Hu, “Regulatory T cell therapy for ischemic stroke: how far from clinical translation?” Translational Stroke Research, vol. 7, no. 5, pp. 415–419, 2016. View at Publisher · View at Google Scholar · View at Scopus
  171. S. Neumann, N. J. Shields, T. Balle, M. Chebib, and A. N. Clarkson, “Innate immunity and inflammation post-stroke: an α7-nicotinic agonist perspective,” International Journal of Molecular Sciences, vol. 16, no. 12, pp. 29029–29046, 2015. View at Publisher · View at Google Scholar · View at Scopus
  172. Z. Wang, L. Xue, T. Wang, X. Wang, and Z. Su, “Infiltration of invariant natural killer T cells occur and accelerate brain infarction in permanent ischemic stroke in mice,” Neuroscience Letters, vol. 633, pp. 62–68, 2016. View at Publisher · View at Google Scholar
  173. T. Homma, S. Kinugawa, M. Takahashi et al., “Activation of invariant natural killer T cells by α-galactosylceramide ameliorates myocardial ischemia/reperfusion injury in mice,” Journal of Molecular and Cellular Cardiology, vol. 62, pp. 179–188, 2013. View at Publisher · View at Google Scholar · View at Scopus
  174. S. De Raedt, A. De Vos, A. Van Binst et al., “High natural killer cell number might identify stroke patients at risk of developing infections,” Neurology—Neuroimmunology Neuroinflammation, vol. 2, no. 2, article no. e71, 2015. View at Publisher · View at Google Scholar
  175. Y. Zhang, Z. Gao, D. Wang et al., “Accumulation of natural killer cells in ischemic brain tissues and the chemotactic effect of IP-10,” Journal of Neuroinflammation, vol. 11, article no. 79, 2014. View at Publisher · View at Google Scholar · View at Scopus
  176. L. Gu, X. Xiong, D. Wei, X. Gao, S. Krams, and H. Zhao, “T cells contribute to stroke-induced lymphopenia in rats,” PLOS ONE, vol. 8, no. 3, Article ID e59602, 2013. View at Publisher · View at Google Scholar · View at Scopus
  177. D. Gill and R. Veltkamp, “Dynamics of T cell responses after stroke,” Current Opinion in Pharmacology, vol. 26, pp. 26–32, 2016. View at Publisher · View at Google Scholar · View at Scopus
  178. J. Klehmet, S. Hoffmann, G. Walter, C. Meisel, and A. Meisel, “Stroke induces specific alteration of T memory compartment controlling auto-reactive CNS antigen-specific T cell responses,” Journal of the Neurological Sciences, vol. 368, pp. 77–83, 2016. View at Publisher · View at Google Scholar · View at Scopus
  179. Y. Hu, Y. Zheng, Y. Wu, B. Ni, and S. Shi, “Imbalance between IL-17A-producing cells and regulatory T cells during ischemic stroke,” Mediators of Inflammation, vol. 2014, Article ID 813045, 8 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  180. X. Wang, H. Li, and S. Ding, “Pre-B-cell colony-enhancing factor protects against apoptotic neuronal death and mitochondrial damage in ischemia,” Scientific Reports, vol. 6, article 32416, 2016. View at Publisher · View at Google Scholar
  181. U. M. Selvaraj, K. Poinsatte, V. Torres, S. B. Ortega, and A. M. Stowe, “Heterogeneity of B cell functions in stroke-related risk, prevention, injury, and repair,” Neurotherapeutics, vol. 13, no. 4, pp. 729–747, 2016. View at Publisher · View at Google Scholar · View at Scopus
  182. X. Ren, K. Akiyoshi, S. Dziennis et al., “Regulatory B cells limit CNS inflammation and neurologic deficits in murine experimental stroke,” Journal of Neuroscience, vol. 31, no. 23, pp. 8556–8563, 2011. View at Publisher · View at Google Scholar · View at Scopus
  183. A. Liesz and C. Kleinschnitz, “Regulatory T cells in post-stroke immune homeostasis,” Translational Stroke Research, vol. 7, no. 4, pp. 313–321, 2016. View at Publisher · View at Google Scholar · View at Scopus
  184. L.-B. Guo, S. Liu, F. Zhang, G.-S. Mao, L.-Z. Sun, and Y. Liu, “The role of eosinophils in stroke: A Pilot Study,” European Review for Medical and Pharmacological Sciences, vol. 19, no. 19, pp. 3643–3648, 2015. View at Google Scholar · View at Scopus
  185. I. Maestrini, D. Strbian, S. Gautier et al., “Higher neutrophil counts before thrombolysis for cerebral ischemia predict worse outcomes,” Neurology, vol. 85, no. 16, pp. 1408–1416, 2015. View at Publisher · View at Google Scholar · View at Scopus
  186. L. Roever and S. R. Levine, “Cerebral hemorrhage following thrombolytic therapy for stroke: are neutrophils really neutral?” Neurology, vol. 85, no. 16, pp. 1360–1361, 2015. View at Publisher · View at Google Scholar · View at Scopus
  187. E. Thonnard-Neumann, “Monocytes and basophilic granulocytes in the cranial circulation of patients with organic brain disorders,” Stroke, vol. 3, no. 3, pp. 286–299, 1972. View at Publisher · View at Google Scholar · View at Scopus
  188. P. J. Lindsberg, D. Strbian, and M.-L. Karjalainen-Lindsberg, “Mast cells as early responders in the regulation of acute blood-brain barrier changes after cerebral ischemia and hemorrhage,” Journal of Cerebral Blood Flow and Metabolism, vol. 30, no. 4, pp. 689–702, 2010. View at Publisher · View at Google Scholar · View at Scopus
  189. M. S. Woo, J. Yang, C. Beltran, and S. Cho, “Cell surface CD36 protein in monocyte/macrophage contributes to phagocytosis during the resolution phase of ischemic stroke in mice,” The Journal of Biological Chemistry, vol. 291, no. 45, pp. 23654–23661, 2016. View at Publisher · View at Google Scholar
  190. S. Wattananit, D. Tornero, N. Graubardt et al., “Monocyte-derived macrophages contribute to spontaneous long-term functional recovery after stroke in mice,” Journal of Neuroscience, vol. 36, no. 15, pp. 4182–4195, 2016. View at Publisher · View at Google Scholar · View at Scopus
  191. A. ElAli and N. J. LeBlanc, “The role of monocytes in ischemic stroke pathobiology: new avenues to explore,” Frontiers in Aging Neuroscience, vol. 8, article no. 29, 2016. View at Publisher · View at Google Scholar · View at Scopus
  192. J. C. Felger, T. Abe, U. W. Kaunzner et al., “Brain dendritic cells in ischemic stroke: time course, activation state, and origin,” Brain, Behavior, and Immunity, vol. 24, no. 5, pp. 724–737, 2010. View at Publisher · View at Google Scholar · View at Scopus
  193. X. Urra, F. Miró, A. Chamorro, and A. M. Planas, “Antigen-specific immune reactions to ischemic stroke,” Frontiers in Cellular Neuroscience, vol. 8, article 278, 2014. View at Publisher · View at Google Scholar · View at Scopus
  194. A. Hug, A. Liesz, B. Muerle et al., “Reduced efficacy of circulating costimulatory cells after focal cerebral ischemia,” Stroke, vol. 42, no. 12, pp. 3580–3586, 2011. View at Publisher · View at Google Scholar · View at Scopus
  195. A. Yilmaz, T. Fuchs, B. Dietel et al., “Transient decrease in circulating dendritic cell precursors after acute stroke: potential recruitment into the brain,” Clinical Science, vol. 118, no. 2, pp. 147–157, 2010. View at Publisher · View at Google Scholar · View at Scopus
  196. K. Duris and J. Lipkova, “The role of microRNA in ischemic and hemorrhagic stroke,” Current Drug Delivery, vol. 14, no. 8, 2017. View at Publisher · View at Google Scholar
  197. J. Kim, G. H. Choi, K. H. Ko et al., “Association of the single nucleotide polymorphisms in microRNAs 130b, 200b, and 495 with ischemic stroke susceptibility and post-stroke mortality,” PLoS ONE, vol. 11, no. 9, Article ID e0162519, 2016. View at Publisher · View at Google Scholar
  198. K. Toyama, J. Spin, and P. Tsao, “Role of microRNAs on blood brain barrier dysfunction in vascular cognitive impairment,” Current Drug Delivery, vol. 13, pp. 1–14, 2016. View at Publisher · View at Google Scholar
  199. A. Karthikeyan, R. Patnala, S. Jadhav, L. Eng-Ang, and S. Dheen, “MicroRNAs: key players in microglia and astrocyte mediated inflammation in CNS pathologies,” Current Medicinal Chemistry, vol. 23, no. 30, pp. 3528–3546, 2016. View at Publisher · View at Google Scholar
  200. M. Vijayan and P. H. Reddy, “Peripheral biomarkers of stroke: focus on circulatory microRNAs,” Biochimica et Biophysica Acta, vol. 1862, no. 10, pp. 1984–1993, 2016. View at Publisher · View at Google Scholar · View at Scopus
  201. R. Zhang, Y. Qin, G. Zhu, Y. Li, and J. Xue, “Low serum miR-320b expression as a novel indicator of carotid atherosclerosis,” Journal of Clinical Neuroscience, vol. 33, pp. 252–258, 2016. View at Publisher · View at Google Scholar
  202. X. Zhou, S. Su, S. Li et al., “MicroRNA-146a down-regulation correlates with neuroprotection and targets pro-apoptotic genes in cerebral ischemic injury in vitro,” Brain Research, vol. 1648, pp. 136–143, 2016. View at Publisher · View at Google Scholar · View at Scopus
  203. P. Wang, J. Liang, Y. Li et al., “Down-regulation of miRNA-30a alleviates cerebral ischemic injury through enhancing Beclin 1-mediated autophagy,” Neurochemical Research, vol. 39, no. 7, pp. 1279–1291, 2014. View at Publisher · View at Google Scholar · View at Scopus
  204. Z. Peng, J. Li, Y. Li et al., “Downregulation of miR-181b in mouse brain following ischemic stroke induces neuroprotection against ischemic injury through targeting heat shock protein A5 and ubiquitin carboxyl-terminal hydrolase isozyme L1,” Journal of Neuroscience Research, vol. 91, no. 10, pp. 1349–1362, 2013. View at Publisher · View at Google Scholar · View at Scopus
  205. P. Wang, N. Zhang, J. Liang, J. Li, S. Han, and J. Li, “Micro-RNA-30a regulates ischemia-induced cell death by targeting heat shock protein HSPA5 in primary cultured cortical neurons and mouse brain after stroke,” Journal of Neuroscience Research, vol. 93, no. 11, pp. 1756–1768, 2015. View at Publisher · View at Google Scholar · View at Scopus
  206. D. A. Duricki, T. H. Hutson, C. Kathe et al., “Delayed intramuscular human neurotrophin-3 improves recovery in adult and elderly rats after stroke,” Brain, vol. 139, no. 1, pp. 259–275, 2016. View at Publisher · View at Google Scholar · View at Scopus
  207. L. Lorente, M. M. Martín, T. Almeida et al., “Serum levels of substance P and mortality in patients with a severe acute ischemic stroke,” International Journal of Molecular Sciences, vol. 17, no. 6, article no. 991, 2016. View at Publisher · View at Google Scholar · View at Scopus
  208. Q. Li, Y. Lin, W. Huang et al., “Serum IL-33 is a novel diagnostic and prognostic biomarker in acute ischemic stroke,” Aging and Disease, vol. 7, no. 5, pp. 614–622, 2016. View at Publisher · View at Google Scholar
  209. S. M. Lloyd-Burton, E. M. York, M. A. Anwar, A. J. Vincent, and A. J. Roskams, “SPARC regulates microgliosis and functional recovery following cortical ischemia,” Journal of Neuroscience, vol. 33, no. 10, pp. 4468–4481, 2013. View at Publisher · View at Google Scholar · View at Scopus
  210. L. Minshu, L. Zhiguo, W. Kristofer, J. Weina, S. Fu-Dong, and L. Qiang, “Abstract 144: astrocyte-derived interleukin-15 accelarates Ischemic Brain Injury Int Stroke Conference,” Stroke, vol. 47, article A144, 2016. View at Google Scholar