Nonpharmacological Interventions in Targeting Pain-Related Brain Plasticity

Figure 1

Illustrated summary of key CAM-responsive centers in the pain brain. Text in colors correspond to each painted brain region in that same color. Due to the single sagittal view of the brain, some areas may not be visualized in their entirety or may not be true to scale. CC: cingulate cortex; IC: insular cortex; IL-1b: interleukin 1-beta; PAG: periaqueductal gray; PFC: prefrontal cortex; S1,2: primary and secondary somatosensory cortices; 5-HT: 5-hydroxytryptamine/serotonin. Text in italics refers to findings from rodent studies.