Modulation Effects of Cordycepin on Voltage-Gated Sodium Channels in Rat Hippocampal CA1 Pyramidal Neurons in the Presence/Absence of Oxygen

<div>Cordycepin suppressed the amplitude of <i>I</i><sub>Na</sub> in a concentration-dependent manner in rat hippocampal CA1 pyramidal neurons. (a) Representative traces of evoked <i>I</i><sub>Na</sub> before and after 80 <i>μ</i>M cordycepin application in a whole-cell patch-clamp configuration. (b) Time courses of the effects of different concentrations of cordycepin (0, 20, 40, 80, and 200 <i>μ</i>M) on <i>I</i><sub>Na</sub> amplitude. Note that the bath application of cordycepin is indicated by a horizontal bar. (b) Effects of different concentrations of cordycepin (20, 40, 80, and 200 <i>μ</i>M) on <i>I</i><sub>Na</sub>. 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Neural Plasticity

fig1

Figure 1

Figure 1: Modulation Effects of Cordycepin on Voltage-Gated Sodium Channels in Rat Hippocampal CA1 Pyramidal Neurons in the Presence/Absence of Oxygen 

Figure 1 | Modulation Effects of Cordycepin on Voltage-Gated Sodium Channels in Rat Hippocampal CA1 Pyramidal Neurons in the Presence/Absence of Oxygen 