Modulation Effects of Cordycepin on Voltage-Gated Sodium Channels in Rat Hippocampal CA1 Pyramidal Neurons in the Presence/Absence of Oxygen
Cordycepin suppressed the amplitude of INa in a concentration-dependent manner in rat hippocampal CA1 pyramidal neurons. (a) Representative traces of evoked INa before and after 80 μM cordycepin application in a whole-cell patch-clamp configuration. (b) Time courses of the effects of different concentrations of cordycepin (0, 20, 40, 80, and 200 μM) on INa amplitude. Note that the bath application of cordycepin is indicated by a horizontal bar. (b) Effects of different concentrations of cordycepin (20, 40, 80, and 200 μM) on INa. The amplitude of INa after cordycepin application was expressed as a percentage of INa amplitude before cordycepin application. , as compared with the control group.
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