Modulation Effects of Cordycepin on Voltage-Gated Sodium Channels in Rat Hippocampal CA1 Pyramidal Neurons in the Presence/Absence of Oxygen
Preapplication of cordycepin-induced mild inhibition on INa attenuated and delayed the subsequent hypoxia-induced rapid dramatic inhibition of INa. (a) Hypoxia for 3 min induced dramatic inhibition on the traces of INa (top traces) in the absence of cordycepin. Reduction on INa induced by hypoxia was attenuated in the presence of cordycepin (bottom traces). (b) Comparison of suppression effects of hypoxia on INa in the absence and presence of cordycepin. The descending slope was indicated by the red line. Hypoxia-induced rapid dramatic reduction on INa was attenuated and delayed in the cordycepin pretreatment group. as compared with the cordycepin pretreatment group.
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