Neuronal-Glial Interactions Maintain Chronic Neuropathic Pain after Spinal Cord Injury

Figure 3

Attenuation of neuronal hyperactivity by spinal treatment with PPF following SCI in rats. (a) Typical spike activity during 10 sec (scale bar) of stimulation in the peripheral field during single neuron recordings from sham (top), SCI + vehicle (middle), and SCI + 10 mM PPF- (bottom) treated rats. (b) After SCI, lumbar spinal wide dynamic range (WDR) dorsal horn neurons displayed significantly increased evoked activity in response to peripheral stimuli (10 seconds each) in the SCI-vehicle group compared to the sham group. Two hours after spinal treatment with 10 mM PPF, this activity was significantly attenuated. In contrast, 1 mM PPF had no effect compared to the vehicle treatment (modified from Gwak et al. [4]). versus the SCI + vehicle group.

(a) Waveforms of activity

(b) Comparison of activity