The Function of FGFR1 Signalling in the Spinal Cord: Therapeutic Approaches Using FGFR1 Ligands after Spinal Cord Injury

Table 2

Different strategies to promote regeneration or neuroprotection using FGF2.

Species	Model	Therapeutic intervention	Outcome	Control	Ref
Rat	Complete transection at T9/T10.; Removal of 4 mm of SC	Rat Schwann cell grafts with FGF2 fibrin glue	Increased survival of NeuN positive cells	Schwann cell graft without FGF2	[70]
Rat	Moderate contusion injury at T10	Osmotic minipump in the lateral ventricle and lumbar thecae sac releasing FGF2 30 min after injury for 1 week	Improvement of BBB score from 12/13 to 15/16. More tissue sparing	Osmotic minipump releasing bovine serum albumin	[71]
Rat	Severe contusion injury at T10	Osmotic minipump in the lateral ventricle and lumbar thecae sac releasing FGF2 30 min after injury for 1 week	Improvement of BBB score from 7–10 to 10–13	Osmotic minipump releasing bovine serum albumin	[72]
Rat	Complete Transection at T10	Direct injection of FGF2 into the surrounding tissue of injury	Improvement of BBB score from 0 to 6	Injection of vehicle	[73]
Mouse	T12 hemisection	Subcutaneous injection of FGF2 during 2 weeks	Better performance on the grid test and mBBB. Reduced level of TNFα leading to decreased microglia and macrophage activation	Injection of vehicle	[74]
Rat	T10 complete transection	Bridging with gel foam containing sciatic nerve fragments and FGF2	Improvement in BBB from 1 to 6	Bridging with gel foam containing sciatic nerve fragments and PBS	[75]