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Neural Plasticity
Volume 2017, Article ID 3682752, 18 pages
Review Article

Zinc in the Monoaminergic Theory of Depression: Its Relationship to Neural Plasticity

1Department of Pharmacobiology, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland
2Department of Animal Physiology, Institute of Biology and Biochemistry, Faculty of Biology and Biotechnology, Maria Curie-Sklodowska University, Akademicka 19, 20-033 Lublin, Poland
3Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, 31-343 Kraków, Poland
4Department of Psychiatry, Medical University of Warsaw, Nowowiejska 27, 00-665 Warszawa, Poland
5Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second Hospital of Jilin University, Changchun, Jilin 130041, China

Correspondence should be addressed to Katarzyna Młyniec; lp.ude.ju@ceinylm.anyzratak

Received 4 November 2016; Accepted 24 January 2017; Published 19 February 2017

Academic Editor: Aijun Li

Copyright © 2017 Urszula Doboszewska et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Preclinical and clinical studies have demonstrated that zinc possesses antidepressant properties and that it may augment the therapy with conventional, that is, monoamine-based, antidepressants. In this review we aim to discuss the role of zinc in the pathophysiology and treatment of depression with regard to the monoamine hypothesis of the disease. Particular attention will be paid to the recently described zinc-sensing GPR39 receptor as well as aspects of zinc deficiency. Furthermore, an attempt will be made to give a possible explanation of the mechanisms by which zinc interacts with the monoamine system in the context of depression and neural plasticity.