Distinct Pattern of Microgliosis in the Olfactory Bulb of Neurodegenerative Proteinopathies

Figure 2

Typical neuropathological hallmarks of Alzheimer’s disease (AD), Parkinson disease dementia/Lewy body disease (PDD/DLB), and frontotemporal lobe degeneration (FTLD) in the GLOM, the GCL, and the OT compared to controls. (a) Aggregates of hyperphosphorylated Tau (p-Tau; brown) were present in all regions analyzed in AD cases. (b) Accumulation of alpha-synuclein (a-Syn; brown) was detected in the GLOM, the GCL, and the OT of PDD/DLB cases, but not in controls. (c) While controls showed a physiological nuclear staining for unphosphorylated TDP43 in all regions investigated, a shift of TDP43 signal (brown) from the nucleus to the cytoplasm, together with a loss of nuclear staining, was observed in the GLOM, GCL, and OT in FTLD. Counterstain with diluted hematoxylin or hemalaun (blue). Scale bars represent 50 μm.

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