Neural Plasticity / 2017 / Article / Tab 1

Review Article

The Contribution of α-Synuclein Spreading to Parkinson’s Disease Synaptopathy

Table 1

First authorTitleYearJournal

Evidences supporting α-synuclein spreading
Braak“Staging of Brain Pathology Related to Sporadic Parkinson’s Disease”2003Neurobiol. Aging
Del Tredici“Sporadic Parkinson’s Disease: Development and Distribution of Alpha-Synuclein Pathology”2016Neuropathol. Appl. Neurobiol.
Iljina“Kinetic Model of the Aggregation of Alpha-Synuclein Provides Insights into Prion-Like Spreading”2016Proc. Natl. Acad. Sci. USA
Oh“Mesenchymal Stem Cells Inhibit Transmission of α-Synuclein by Modulating Clathrin-Mediated Endocytosis in a Parkinsonian Model”2016Cell Rep.
Helwig“Brain Propagation of Transduced Alpha-Synuclein Involves Non-Fibrillar Protein Species and Is Enhanced in Alpha-Synuclein Null Mice”2016Brain
Bernis“Prion-Like Propagation of Human Brain-Derived Alpha-Synuclein in Transgenic Mice Expressing Human Wild-Type Alpha-Synuclein”2015Acta Neuropathol. Commun.
Illes-Toth“Distinct Higher-Order Alpha-Synuclein Oligomers Induce Intracellular Aggregation”2015Biochem. J.
Ulusoy“Neuron-to-Neuron α-Synuclein Propagation In Vivo Is Independent of Neuronal Injury”2015Acta Neuropathol. Commun.
Stuendl“Induction of α-Synuclein Aggregate Formation by CSF Exosomes from Patients with Parkinson’s Disease and Dementia with Lewy Bodies”2016Brain
Prusiner“Evidence for α-Synuclein Prions Causing Multiple System Atrophy in Humans with Parkinsonism”2015Proc. Natl. Acad. Sci. USA
Masuda-Suzukake“Pathological Alpha-Synuclein Propagates through Neural Networks”2014Acta Neuropathol. Commun.
Sacino“Brain Injection of Alpha-Synuclein Induces Multiple Proteinopathies, Gliosis, and a Neuronal Injury Marker”2014J. Neurosci.
Kovacs“Intracellular Processing of Disease-Associated α-Synuclein in the Human Brain Suggests Prion-Like Cell-to-Cell Spread”2014Neurobiol. Dis.
Recasens“Lewy Body Extracts from Parkinson Disease Brains Trigger α-Synuclein Pathology and Neurodegeneration in Mice and Monkeys”2014Ann. Neurol.
Ulusoy“Caudo-Rostral Brain Spreading of α-Synuclein through Vagal Connections”2013EMBO Mol. Med.
Masuda-Suzukake“Prion-Like Spreading of Pathological α-Synuclein in Brain”2013Brain
Angot“Alpha-Synuclein Cell-to-Cell Transfer and Seeding in Grafted Dopaminergic Neurons In Vivo2012PLoS One
Luk“Intracerebral Inoculation of Pathological Alpha-Synuclein Initiates a Rapidly Progressive Neurodegenerative Alpha-Synucleinopathy in Mice”2012J. Exp. Med.
Luk“Pathological Alpha-Synuclein Transmission Initiates Parkinson-Like Neurodegeneration in Nontransgenic Mice”2012Science
Kordower“Transfer of Host-Derived Alpha Synuclein to Grafted Dopaminergic Neurons in Rat”2011Neurobiol. Dis.
Hansen“Alpha-Synuclein Propagates from Mouse Brain to Grafted Dopaminergic Neurons and Seeds Aggregation in Cultured Human Cells”2011J. Clin. Invest.
Danzer“Seeding Induced by Alpha-Synuclein Oligomers Provides Evidence for Spreading of Alpha-Synuclein Pathology”2009J. Neurochem.
Kordower“Transplanted Dopaminergic Neurons Develop PD Pathologic Changes: A Second Case Report”2008Mov. Disord.
Kordower“Lewy Body-Like Pathology in Long-Term Embryonic Nigral Transplants in Parkinson’s Disease”2008Nat. Med.
Li“Lewy Bodies in Grafted Neurons in Subjects with Parkinson’s Disease Suggest Host-to-Graft Disease Propagation”2008Nat. Med.

Evidences confuting α-synuclein spreading
Sumikura“Distribution of Alpha-Synuclein in the Spinal Cord and Dorsal Root Ganglia in an Autopsy Cohort of Elderly Persons”2015Acta Neuropathol. Commun.
Sacino“Amyloidogenic α-Synuclein Seeds Do Not Invariably Induce Rapid, Widespread Pathology in Mice”2014Acta Neuropathol.
Halliday“The Progression of Pathology in Parkinson’s Disease”2010Ann. N. Y. Acad. Sci.
Jang“Non-Classical Exocytosis of Alpha-Synuclein Is Sensitive to Folding States and Promoted under Stress Conditions”2010J. Neurochem.
Hawkes“Parkinson’s Disease and Aging: Same or Different Process?”2008Mov. Disord.
Kalaitzakis“Controversies over the Staging of Alpha-Synuclein Pathology in Parkinson’s Disease”2008Acta Neuropathol.

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