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Neural Plasticity
Volume 2017, Article ID 5181925, 9 pages
Review Article

HINT1 in Neuropsychiatric Diseases: A Potential Neuroplastic Mediator

1College of Medicine & Forensics, Key Laboratory of the Health Ministry for Forensic Medicine, Key Laboratory of Environment and Genes Related to Diseases of the Education Ministry, Xi’an Jiaotong University Health Science Center, Xi’an 710061, China
2Department of Cardiology, Shaanxi Provincial People’s Hospital, Xi’an 710068, China
3Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland Baltimore, Baltimore MD 21201, USA
4Department of Psychiatry, First Affiliated Hospital of Xi’an Jiaotong University Health Science Center, Xi’an, China

Correspondence should be addressed to Yonghui Dang; nc.ude.utjx.liam@hydysp

Received 14 April 2017; Revised 23 August 2017; Accepted 18 September 2017; Published 30 October 2017

Academic Editor: Bingjin Li

Copyright © 2017 Peng Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Although many studies have investigated the functions of histidine triad nucleotide-binding protein 1 (HINT1), its roles in neurobiological processes remain to be fully elucidated. As a member of the histidine triad (HIT) enzyme superfamily, HINT1 is distributed in almost every organ and has both enzymatic and nonenzymatic activity. Accumulating clinical and preclinical evidence suggests that HINT1 may play an important role as a neuroplastic mediator in neuropsychiatric diseases, such as schizophrenia, inherited peripheral neuropathies, mood disorders, and drug addiction. Though our knowledge of HINT1 is limited, it is believed that further research on the neuropathological functions of HINT1 would eventually benefit patients with neuropsychiatric and even psychosomatic diseases.