The Rapid Effect of Bisphenol-A on Long-Term Potentiation in Hippocampus Involves Estrogen Receptors and ERK Activation

Figure 3

ERK signal pathway was involved in BPA-enhanced LTP. Pretreatment with ERK inhibitor U0126 for 30 min before BPA 100 nM (open triangles, ) completely blocked LTP compared with controls. (b) Pretreatment with BPA 100 nM 30 min before the ERK inhibitor (open squares, ) application remarkably decreased the BPA effect as compared with BPA 100 nM alone (open squares). (c, d) Figure columns showing the average fEPSP amplitudes at 60 min after HFS in separate perfusion or coperfusion of BPA 100 nM and U0 126 30 μM, as compared to the control, as compared to the BPA 100 nM. Solid and dashed example traces before HFS and after HFS, respectively.

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