The Rapid Effect of Bisphenol-A on Long-Term Potentiation in Hippocampus Involves Estrogen Receptors and ERK Activation

Figure 4

The enhancement of BPA on hippocampal LTP was abolished by E₂ treatment. Enhanced LTP by E₂ (10 nM) in hippocampal area DG (open triangles, ). Coadministration of BPA 100 nM with E₂ (filled triangles, ) had no effect on LTP compared with untreated controls. (b) Pretreatment by E₂ enhanced the pre-HFS EPSP amplitudes, as compared to controls, as compared to the E₂ 10 nM. (c) Comparison of different groups the fEPSP amplitudes at 60 min. E₂ had no effect on LTP compared with untreated controls without baseline increase in EPSP amplitude (before the HFS). as compared to the control, as compared to the BPA 100 nM. Solid and dashed traces are examples of before treatment, after treatment, and after HFS, respectively.

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