Hippocampal Regulation of Postsynaptic Density Homer1 by Associative Learning

Figure 2

(a) Representative autoradiographs of coronal rat brain sections (−3.5 mm posterior to the bregma) hybridized with oligonucleotide probes targeting Homer1a, Ania-3, long Homer1, or Arc. (b–e) Hippocampal mRNA expression of (b) Homer1a, (c) Ania-3, (d) long Homer1, and (e) Arc following contextual fear conditioning (CFC). mRNA expression from the CA1, CA3, and dentate gyrus (DG) regions is represented by mean ± SEM standardised optical density values, normalised to naïve controls (100%). Brains were dissected 30 min, 2 h, 4 h, or 24 h after conditioning. per group. Asterisks represent significance of the groups versus naïve control (, , and ).

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