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Neural Plasticity
Volume 2017 (2017), Article ID 6090312, 8 pages
Research Article

Emulation with Organic Memristive Devices of Impairment of LTP Mechanism in Neurodegenerative Disease Pathology

1IMEM-CNR, 43124 Parma, Italy
2Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia

Correspondence should be addressed to Silvia Battistoni

Received 2 February 2017; Accepted 13 April 2017; Published 19 June 2017

Academic Editor: Malgorzata Kossut

Copyright © 2017 Silvia Battistoni et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We explore and demonstrate the extension of the synapse-mimicking properties of memristive devices to a dysfunctional synapse as it occurs in the Alzheimer’s disease (AD) pathology. The ability of memristive devices to reproduce synapse properties such as LTP, LTD, and STDP has been already widely demonstrated, and moreover, they were used for developing artificial neuron networks (perceptrons) able to simulate the information transmission in a cell network. However, a major progress would be to extend the common sense of neuromorphic device even to the case of dysfunction of natural synapses. Can memristors efficiently simulate them? We provide here evidences of the ability of emulating the dysfunctional synaptic behavior typical of the AD pathology with organic memristive devices considering the effect of the disease not only on a single synapse but also in the case of a neural network, composed by numerous synapses.