Evidence of Presynaptic Localization and Function of the c-Jun N-Terminal Kinase

Figure 3

JBD is crucial for SNARE interaction with JNK. (a) Sequence alignment between Syntaxin-1 and Syntaxin-2. The JBDs are underlined in red. (b) Sequence of Snap25 with the JBD underlined in red. On top of panels (a) and (b) the canonical JBD pattern is also reported. (c) Best JNK-Syntaxin complex resulting from the docking predictions. JNK is shown in light blue and Syntaxin in gold. The lateral chains of the residues belonging to the JBD are shown in red. (d) Best complex of the JNK-Snap25 docking results. Also in this case JNK is depicted in light blue while Snap25 is shown in light brown. The lateral chains of the residues of the JBD in Snap25 are reported in red.

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