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Neural Plasticity
Volume 2017, Article ID 6871089, 11 pages
Review Article

The Role of Neural Plasticity in Depression: From Hippocampus to Prefrontal Cortex

1Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, China
2Anesthesiology Department, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, China
3Anesthesiology Department, The Third Hospital of Jilin University, 126 Xiantai Street, Changchun 130033, China

Correspondence should be addressed to Wei Yang; nc.ude.ulj@2002gnayw and Ranji Cui; nc.ude.ulj@ijnariuc

Received 3 November 2016; Accepted 4 January 2017; Published 26 January 2017

Academic Editor: Aijun Li

Copyright © 2017 Wei Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Neural plasticity, a fundamental mechanism of neuronal adaptation, is disrupted in depression. The changes in neural plasticity induced by stress and other negative stimuli play a significant role in the onset and development of depression. Antidepressant treatments have also been found to exert their antidepressant effects through regulatory effects on neural plasticity. However, the detailed mechanisms of neural plasticity in depression still remain unclear. Therefore, in this review, we summarize the recent literature to elaborate the possible mechanistic role of neural plasticity in depression. Taken together, these findings may pave the way for future progress in neural plasticity studies.