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Neural Plasticity
Volume 2017, Article ID 6986983, 10 pages
Review Article

Effect of Hypoxic Injury in Mood Disorder

Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second Hospital of Jilin University, Changchun, Jilin 130041, China

Correspondence should be addressed to Junling Yang; nc.ude.ulj@gnilnuj and Ranji Cui; nc.ude.ulj@ijnariuc

Received 24 March 2017; Revised 26 May 2017; Accepted 6 June 2017; Published 22 June 2017

Academic Editor: Aijun Li

Copyright © 2017 Fenglian Zhao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Hypoxemia is a common complication of the diseases associated with the central nervous system, and neurons are highly sensitive to the availability of oxygen. Neuroplasticity is an important property of the neural system controlling breathing, memory, and cognitive ability. However, the underlying mechanism has not yet been clearly elucidated. In recent years, several pieces of evidence have highlighted the effect of hypoxic injury on neuronal plasticity in the pathogenesis and treatment of mood disorder. Therefore, the present study reviewed the relevant articles regarding hypoxic injury and neuronal plasticity and discussed the pathological changes and physiological functions of neurons in hypoxemia in order to provide a translational perspective to the relevance of hypoxic injury and mood disorder.