Long-Term High Salt Intake Involves Reduced SK Currents and Increased Excitability of PVN Neurons with Projections to the Rostral Ventrolateral Medulla in Rats

Figure 2

HS intake reduces SK currents in PVN-RVLM neurons. (a) The representative voltage-clamp recording traces from NS PVN-RVLM neuron. An outward tail current (black) prior to apamin and the outward tail current (red) after apamin with the total SK current (inset) from the subtraction of the apamin trace (red) from the nonapamin trace (black). (b) The representative voltage-clamp recording traces from HS PVN-RVLM neuron. An outward tail current (blue) prior to apamin and the outward tail current (purple) after apamin with the total SK current (inset) from the subtraction of the apamin trace (purple) from the nonapamin trace (blue). (c) Summary data for apamin-sensitive SK currents between NS controls and the HS group. (d) Summary data for SK current density between NS controls and the HS group showed a significant reduction in SK current density ( versus NS controls, unpaired t-test).

(a)

(b)

(c)

(d)