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Neural Plasticity
Volume 2017, Article ID 7407241, 9 pages
Research Article

Increased Alpha-Rhythm Dynamic Range Promotes Recovery from Visuospatial Neglect: A Neurofeedback Study

1Laboratory Behavioral Neurology and Imaging of Cognition, Department of Neuroscience, University Medical Center and Campus Biotech, Geneva, Switzerland
2Romand Clinic of Readaptation, SUVA, Sion, Switzerland
3Neuropsychology Unit, Department of Neurology, University Hospital of Geneva, Geneva, Switzerland

Correspondence should be addressed to Tomas Ros; moc.liamg@sor.t.rd

Received 7 December 2016; Accepted 8 March 2017; Published 26 April 2017

Academic Editor: Bruno Poucet

Copyright © 2017 Tomas Ros et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Despite recent attempts to use electroencephalogram (EEG) neurofeedback (NFB) as a tool for rehabilitation of motor stroke, its potential for improving neurological impairments of attention—such as visuospatial neglect—remains underexplored. It is also unclear to what extent changes in cortical oscillations contribute to the pathophysiology of neglect, or its recovery. Utilizing EEG-NFB, we sought to causally manipulate alpha oscillations in 5 right-hemisphere stroke patients in order to explore their role in visuospatial neglect. Patients trained to reduce alpha oscillations from their right posterior parietal cortex (rPPC) for 20 minutes daily, over 6 days. Patients demonstrated successful NFB learning between training sessions, denoted by improved regulation of alpha oscillations from rPPC. We observed a significant negative correlation between visuospatial search deficits (i.e., cancellation test) and reestablishment of spontaneous alpha-rhythm dynamic range (i.e., its amplitude variability). Our findings support the use of NFB as a tool for investigating neuroplastic recovery after stroke and suggest reinstatement of intact parietal alpha oscillations as a promising target for reversing attentional deficits. Specifically, we demonstrate for the first time the feasibility of EEG-NFB in neglect patients and provide evidence that targeting alpha amplitude variability might constitute a valuable marker for clinical symptoms and self-regulation.