Transglutaminase 2 Induces Deficits in Social Behavior in Mice

Figure 2

TG2 overexpression in the PFC induces social interaction deficits in mice. (a) Schematic representation of stereotaxic injection of control or TG2 lentiviral particles into the mouse PFC. (b) Increase in TG2 expression in the PFC of mice injected with TG2 lentiviral particles. Top: representative blot. Bottom: quantification of TG2 normalized to actin. Protein levels were measured by western blot analysis. ; Student’s -test. (control) and 4 (TG2). (c–d) TG2 overexpression induced deficits in social behavior. (c) The three-chamber social interaction test. (E vs. M); two-way ANOVA. (d) Reciprocal social interaction test. vs. con group; one-way ANOVA. mice per group. Data are expressed as mean ± SEM. M: chamber housing stranger mouse; E: chamber housing an empty cage; C: center.

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