Neural Plasticity / 2018 / Article / Fig 2

Research Article

Activation of Phosphotyrosine-Mediated Signaling Pathways in the Cortex and Spinal Cord of SOD1G93A, a Mouse Model of Familial Amyotrophic Lateral Sclerosis

Figure 2

The activity of src and fyn kinases is upregulated in the cortex and spinal cord of SOD1G93A mice. In vitro kinase activity of src (upper panels) and fyn (lower panels) isolated from the cortex (a) and spinal cord (b) obtained from control, SOD1WT, and SOD1G93A mice. Enolase was used as an exogenous substrate. The [32P]-labelled proteins were revealed on dried gel by exposure to X-ray film, and the extent of [32P] incorporation in the substrate enolase was quantified using phosphor imager instrument and expressed as percentage of the value of the control samples (100%). The bar graphs represent the means ± SEM of four independent experiments. Significantly different from SOD1WT and control (, Kruskal-Wallis followed by Dunn’s test).

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