Effects of Antipsychotic Drugs on the Epigenetic Modification of Brain-Derived Neurotrophic Factor Gene Expression in the Hippocampi of Chronic Restraint Stress Rats

<div>Effects of antipsychotic drugs on total and exon IV brain-derived neurotrophic factor (BDNF) mRNA levels in the rat hippocampus. Rats were given a daily injection of either vehicle (VEH), olanzapine (OLA), or haloperidol (HAL) for 21 d in conjunction with either exposure to (+ stress) or no exposure to (− stress) restraint stress. The mRNA levels of total BDNF (a) and exon IV BDNF (b) in the rat hippocampus were measured using a quantitative real-time polymerase chain reaction (qRT-PCR) procedure. 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Neural Plasticity

fig1

Figure 1

Figure 1: Effects of Antipsychotic Drugs on the Epigenetic Modification of Brain-Derived Neurotrophic Factor Gene Expression in the Hippocampi of Chronic Restraint Stress Rats 

Figure 1 | Effects of Antipsychotic Drugs on the Epigenetic Modification of Brain-Derived Neurotrophic Factor Gene Expression in the Hippocampi of Chronic Restraint Stress Rats 