Effects of Antipsychotic Drugs on the Epigenetic Modification of Brain-Derived Neurotrophic Factor Gene Expression in the Hippocampi of Chronic Restraint Stress Rats

<div>Effects of antipsychotic drugs on acetylated histone H3 and methyl CpG-binding protein 2 (MeCP2) levels at BDNF promoter IV in the rat hippocampus. Rats were given a daily injection of either VEH, OLA, or HAL for 21 d in conjunction with either + stress or − stress. Chromatin immunoprecipitation (ChIP) assays were performed to measure the levels of acetylated H3 (a) and MeCP2 (b) at BDNF promoter IV in the rat hippocampus using specific antibodies. 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Neural Plasticity

fig2

Figure 2

Figure 2: Effects of Antipsychotic Drugs on the Epigenetic Modification of Brain-Derived Neurotrophic Factor Gene Expression in the Hippocampi of Chronic Restraint Stress Rats 

Figure 2 | Effects of Antipsychotic Drugs on the Epigenetic Modification of Brain-Derived Neurotrophic Factor Gene Expression in the Hippocampi of Chronic Restraint Stress Rats 