Effects of Antipsychotic Drugs on the Epigenetic Modification of Brain-Derived Neurotrophic Factor Gene Expression in the Hippocampi of Chronic Restraint Stress Rats

Table 1

Individual-level data for each group analyzed by qRT-PCR and ChIP.

	− Restraint stress			+ Restraint stress
	VEH	OLA	HAL	VEH	OLA	HAL
Total BDNF mRNA	1.00 ± 0.07	1.38 ± 0.05	0.89 ± 0.09	0.54 ± 0.04	1.03 ± 0.10	0.65 ± 0.14
BDNF exon IV mRNA	1.00 ± 0.06	1.55 ± 0.05	0.99 ± 0.07	0.55 ± 0.06	1.10 ± 0.12	0.57 ± 0.26
Acetyl-H3	1.00 ± 0.20	1.44 ± 0.22	1.00 ± 0.37	0.37 ± 0.40	0.88 ± 0.39	0.36 ± 0.29
MeCP2	1.00 ± 0.37	0.64 ± 0.21	1.21 ± 0.27	1.51 ± 0.28	0.73 ± 0.28	1.25 ± 0.22
HDAC5 mRNA	1.00 ± 0.05	0.80 ± 0.06	1.06 ± 0.13	1.47 ± 0.06	0.72 ± 0.14	1.35 ± 0.07
DNMT1 mRNA	1.00 ± 0.09	0.73 ± 0.08	1.05 ± 0.09	1.44 ± 0.11	0.81 ± 0.14	1.20 ± 0.08
DNMT3a mRNA	1.00 ± 0.04	0.64 ± 0.05	1.09 ± 0.09	1.80 ± 0.12	1.21 ± 0.09	1.72 ± 0.13