|
| Authors (year) | Sample size | Age (mean) | MS duration (years) | EDSS (median) | Intervention(s) (setting and schedule) | Technique(s) | Functional main result(s) | Clinical correlation(s) | Structural correlation(s) |
|
| Filippi al. (2012) [75] | 10 RR
Active
10 RR
Control | 46.7 [25.0–64.0]
44.8 [28–60] | 13.5 [1.0–28.0]
15.5 [1.0–28.0] | 2.0 [1.5–4.0]
2.5 [1–4.0.0] | 12 weeks of computer-assisted cognitive rehabilitation | ICA | FC in the DMN, SPN, and EFN increase or stay stable in the active group | FC changes correlates with cognitive improvement | — |
| Petsas et al. (2015) [74] | 20 RR
14 HS | 34.0 (6.0)
31.0 (5.0) | 13.5 (16.5)
— | 1.5 [0.0–3.0]
— | 25 minutes of right repetitive thumb flexions | ICA | Greater increment of FC in the cerebellum | No significant results | Correlation between FC in SMN and lesion volume |
| Boutiére et al. (2016) [77] | 9MS
Active
7 SP, 8 MS
Control | 48.2 (9.4)
55.4 (11.1) | 12.2 (8.2)
18.7 (11.0) | 6.0 [4.0–7.0]
6.0 [6.0–6.5] | 13 consecutive days of theta burst stimulation of the motor cortex. | Graph theory | Laterality increases at the end of stimulation and returns to baseline after two weeks | Positive correlation with improvement of spasticity | — |
| De Giglio et al. (2016) [76] | 11 MS Active
11 MS control | 42.0 (8.8)
41.1 (4.4) | 12.9 (5.7)
— | 2.0 [2.0–7.0]
— | 8-weeks of video game-based cognitive rehabilitation | Seed (thalamus) | Increase FC in the posterior cingulate, precuneus, and parietal cortex and decrement of FC in the cerebellum and L DLPFC | Positive correlation of FC in the parietal cortex and cognitive improvement | — |
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