Cholinergic Mechanisms of Target Oddball Stimuli Detection: The Late “P300-Like” Event-Related Potential in Rats

Figure 3

Grand average auditory-evoked waveforms recorded from the frontal left electrodes in rats performing in the auditory oddball discrimination task. Auditory potentials to target tone (red curve) stimuli consist of early positive (P1) and negative components (N1) and a late positive component (P300-like), which is preceded by a negative component (N2). In the late P300-like component, we could distinguish early and late positive waves occurring between 200 and 500 ms after target stimuli onset. Those components were smaller in AEPs to nontarget stimuli (black curve), and no P300 response was revealed by nontarget stimuli. This grand averaged waveform was calculated for all animals.