Newly Generated Cells in the Dentate Gyrus Differentially Respond to Brief Spatial Exploration and Forced Swim in Adult Female Balb/C Mice

Figure 3

Neuronal activation in the dentate gyrus of adult mice after brief spatial exploration. (a) Experimental design. Female Balb/C mice kept under standard housing conditions were exposed to environment A, A + A, or A + B for 5 minutes as is described in Materials and Methods. (b) Representative micrographs of Arc-labelled cells in mice exposed to the different environments are shown. Scale bar in B is equal to 100 μm. Insets correspond to high-power images of Arc-positive cells. The scale bar in the inserts is equal to 40 μm. (c) Quantification of Arc-labelled cells showed more in the A + A and A + B groups than in the control (CTL) group. Asterisks indicate . Crosses indicate a significant difference between A and A + A () or A and A + B (). Data are expressed as the of the absolute number of Arc-cells, and comparisons in (c) were performed with a one-way ANOVA followed by Student-Newman-Keuls post hoc test. per group.

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